Results 181 to 190 of about 43,956 (257)

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Caregiver attitudes towards HIV testing and contraceptive services for adolescents in Tanzania. [PDF]

open access: yesAIDS Care
Alexander K   +8 more
europepmc   +1 more source

Phase 1/2 Study of Crizotinib in Children With Relapsed/Refractory ALK‐Positive Anaplastic Large Cell Lymphoma or Neuroblastoma in Japan

open access: yesCancer Science, EarlyView.
The safety and antitumor activity of crizotinib at a dose of 165 mg/m2 BID were evaluated in 16 patients with ALK‐positive ALCL in Japan. The most common grade 3 or 4 adverse event was neutropenia. The steady‐state Cmax and AUCtau of crizotinib at 165 mg/m2 BID were higher than expected. The objective response rate was 72.7% (90% CI, 43.6%–92.1%) among
Tetsuya Mori   +12 more
wiley   +1 more source

Impact of Sequential Ramucirumab Plus Docetaxel After PD‐1 Inhibitors on Anti‐PD‐1 Antibody‐Bound T‐Cell Dynamics and Clinical Outcomes

open access: yesCancer Science, EarlyView.
Ramucirumab (RAM) plus docetaxel (DOC) after PD‐1 inhibitors showed clinical activity, with responders exhibiting maintained anti–PD‐1 (IgG4+)‐bound CD8+ T cells and decreased IgG4+ Tregs. A sequential strategy of administering RAM plus DOC during persistent anti–PD‐1 antibody binding may be beneficial in patients with advanced non‐small cell lung ...
Kinnosuke Matsumoto   +20 more
wiley   +1 more source

Self‐reported mental health and the Dobbs decision: Variation by State abortion laws

open access: yesContemporary Economic Policy, Volume 43, Issue 2, Page 199-225, April 2025.
Abstract When a US Supreme Court ruling allowed states to ban abortion, women of childbearing age in the states where abortion became illegal reported higher rates of anxiety symptoms compared to similar‐aged women in other states and older women in the same states.
J. Michael Collins, Vivekananda Das
wiley   +1 more source

Reproductive health in the liver transplant recipient. [PDF]

open access: yesLiver Transpl
Dukewich M   +3 more
europepmc   +1 more source

Intravenous immunoglobulin and febrile status epilepticus in children with Dravet syndrome: A retrospective multicentre study

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
This multicenter retrospective study evaluated the use of intravenous immunoglobulin (IVIG) in 14 children with Dravet syndrome as a preventive strategy against febrile status epilepticus. Over a 6‐month period, IVIG was associated with a significant reduction in hospitalizations for febrile status epilepticus.
Romane Marc   +9 more
wiley   +1 more source

Combined Oral Contraceptives and the Risk of Thrombosis. [PDF]

open access: yesInt J Mol Sci
Khizroeva J   +13 more
europepmc   +1 more source

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