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Update on male hormonal contraceptive agents
Expert Opinion on Investigational Drugs, 2004There remains a need for new acceptable and effective male contraceptives to increase the choice for couples throughout the world. There have been no recent advances in available male contraceptive methods although a number of promising approaches have been identified, of which the hormonal approach is currently undergoing clinical investigation.
Melanie, Walton, Richard A, Anderson
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Ulipristal acetate as an emergency contraceptive agent
Expert Opinion on Pharmacotherapy, 2012Emergency contraceptive agents play a crucial role in preventing unplanned pregnancy. These agents and devices have been studied since the 1960s and have had varied results in terms of side effects and efficacy. A new oral tablet for emergency contraception (EC), ulipristal acetate (UPA) , is a selective progesterone receptor modulator and can be used ...
Alan M, Martinez, Michael A, Thomas
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Newer Agents for Hormonal Contraception in the Male
Trends in Endocrinology & Metabolism, 2000Efforts to create a hormonal contraceptive for men use testosterone to suppress the production of pituitary gonadotropins and, hence, spermatogenesis. However, conventional testosterone must be administered by frequent injection, and when given alone, is not 100% effective.
J K, Amory, W J, Bremner
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Oral contraceptive agents: current status
The American Journal of Surgery, 1988Oral contraceptives are the most widely prescribed and ingested drug in human history. The difficulty in establishing their clear-cut side effects is compounded by the rarity of these side effects and their occurrence with multiple other factors and cofactors that may be etiologically more important.
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Metallic copper as an intrauterine contraceptive agent
American Journal of Obstetrics and Gynecology, 1973Abstract Some of the biological aspects of copper relevant to reproductive processes are reviewed. Included are cyclic variations in the concentrations of copper in the endometrium, uterine fluid, cervical mucus, and serum as modified by the presence of intrauterine metallic copper and after its removal. Variations in the endometrial enzymes, namely,
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Effects of oral contraceptive agents on carbohydrate metabolism
Journal of Steroid Biochemistry, 1975This is a survey of recent data regarding the influence of conventional contraceptive steroids on carbohydrate metabolism. Evidence indicates that a continuum of sensitivity to sex steroids exists and the deterioration of glucose tolerance appears to parallel the preexisting state of pancreatic beta cell function.
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Endogenous Antispermatogenic Agents: Prospects for Male Contraception
Annual Review of Pharmacology and Toxicology, 1978A review of endogenous antispermatogenic agents as prospects for male contraception is reported. It is demonstrated that endogenous compounds exert regulatory influences at 4 major levels in the male: 1) between germ cells; 2) between Sertoli and germ cells; 3) between Leydig cells and seminiferous tubules; and 4) between the central nervous system
L L, Ewing, B, Robaire
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Hypertension Secondary to Contraceptive Agents
1982Agents used to prevent conception are generally of five main types: 1) mechanical barriers, e.g. sheaths and cervical diaphragms. 2) intra-uterine devices; these may be inert plastic, or contain a metal such as copper, or be impregnated with a hormone such as progesterone. 3) spermicidal creams, jelly or paste. 4)
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[Contraceptive agents and risk of thrombosis].
Praxis, 1997In the late sixties and seventies, publications of the Royal College of General Practitioners in England reported that in women using oral contraceptiva the incidence of venous thromboembolism is increased by two to four fold. Moreover, it was demonstrated, that these alterations in coagulation were induced by ethinylestradiol in a dose dependent ...
E, Maurer-Major, P J, Keller
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