Results 141 to 150 of about 47,852 (311)

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

Andrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik, Jessica M. Snyder, Haley A. Martin, John K. Amory   +3 more
wiley   +1 more source

Estetrol‐based combined oral contraceptives: A systematic review of clinical outcomes

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
This systematic review summarizes clinical outcomes of estetrol‐containing combined oral contraceptives, showing reliable contraceptive efficacy, predictable bleeding patterns, improved well‐being, and a favorable hemostatic and metabolic profile, suggesting a promising and potentially safer alternative to ethinylestradiol‐based formulations.
Mathilde Råberg, Ingeborg Rose Vad, Kara Hildur Axelsdóttir, Ellen Christine Leth Løkkegaard   +3 more
wiley   +1 more source

Fat reduction mediates the efficacy of intensive lifestyle interventions on fertility‐sparing treatment in overweight patients with endometrial cancer and intraepithelial neoplasia

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Intensive lifestyle interventions‐based weight management targeting fat reduction may enhance fertility‐sparing treatment outcomes in overweight patients with endometrial cancer or its precursor. Our findings advocate the integration of body composition‐guided weight management into standardized protocols.
Sijia Liu, Li Li, Pengfei Wu, Lulu Wang, Qujia Gama, Manrong Wang, Jinyu Zhang, Liping Jin, Xuezhen Luo, Weiwei Shan, Bingyi Yang   +10 more
wiley   +1 more source

Probiotic supplementation during pregnancy for vaginal microbiota improvement and pathogen clearance: A systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Probiotic supplementation during pregnancy shows a modest, non‐robust increase in Group B Streptococcus decolonization, with no consistent benefit for bacterial vaginosis or vulvovaginal candidiasis. Probiotics may serve as a non‐antibiotic adjunct, but standardized regimens and ecological diagnostic frameworks are required.
Zimo Liu, Roujie Huang, Tianshu Sun, Lan Zhu   +3 more
wiley   +1 more source

Cardiovascular Health Was Moderate in Austrian Adolescents and Showed an Inverse Relationship With High‐Sensitivity C‐Reactive Protein Levels

Acta Paediatrica, EarlyView.
ABSTRACT Aim This Prospective, Community‐Based Cohort Study Investigated Cardiovascular Health and Its Association With Low‐Grade Inflammation in Adolescents. Methods Data were collected by specially trained medical staff from 1379 Austrian adolescents aged 14–19 years from 3 February 2021 to 28 February 2023.
Katharina Mueller, Alex Messner, Johannes Nairz, Ursula Kiechl‐Kohlendorfer, Michael Knoflach, Sophia Zollner‐Kiechl, Early Vascular Ageing in the Youth study group   +6 more
wiley   +1 more source

Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis

BJU International, EarlyView.
Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon, Asaad Ahmad, Natalie Lott, Alison Blatt   +3 more
wiley   +1 more source

Hormonal contraceptives and EEG biomarkers for antidepressant treatment response in women. [PDF]

Commun Med (Lond)
Jensen KHR, Juvik AK, Larsen SV, Andersen MT, Frokjaer VG, Jørgensen MB, Ip CT.   +6 more
europepmc   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

A Tale as Old as Time: Contraception Concerns in the 21st Century. [PDF]

Open Access J Contracept
Bottomley-Wise RM, Woodward A, Okanlawon A, Mason-Jones AJ.   +3 more
europepmc   +1 more source

Determination of serum protein binding of 3H-ACTH using dextran gel filtration and desity gradient centrifugation [PDF]

, 1967
Kluge, F., Schwarz, K., Scriba, Peter Christian, Werder, Klaus von   +3 more
core   +1 more source