Results 1 to 10 of about 2,263 (160)

Pharmacological and metabolic effects of drospirenone as a progestin-only pill compared to combined formulations with estrogen

Women's Health, 2023
The spironolactone derivative drospirenone is combined with ethinylestradiol or estetrol in combined oral contraceptives. Formulations with 17-β-estradiol are used to treat climacteric symptoms.
Pedro-Antonio Regidor
exaly   +2 more sources

The benefits of estetrol addition to drospirenone for contraception

AJOG Global Reports, 2023
Ethinylestradiol and drospirenone combined oral contraceptive formulations have been marketed for >20 years. Drospirenone has antimineralocorticoid and anti-androgenic effects that may offer several health benefits.
Kristina Gemzell-Danielsson, Ali Kubba, Jonathan Douxfils   +2 more
exaly   +3 more sources

Drospirenone [PDF]

Hypertension, 2006
Drospirenone (DRSP) is a compound with mingled identities having been viewed as a diuretic,1 a progestational agent,2 and/or an antimineralocorticoid agent with an ability to reduce blood pressure (BP).3–6 The multiple personalities of this compound can be seen by examining the position adopted by the United States Anti-Doping Agency on its use as a ...
europepmc   +2 more sources

Drospirenone promotes apoptosis in ectopic but inhibits proliferation in eutopic human endometrial stromal cells. [PDF]

PLoS ONE
BackgroundEndometriosis is a complex gynecological condition characterized by endometrial tissue growing outside the uterus. In many in vitro studies, almost all progestins have indicated the anti-proliferation and apoptosis of endometriotic stromal ...
Thanyarat Wongwananuruk, Somsin Petyim, Pawitra Suwannalert, Kittima Tungprasertpol, Supatra Klaymook   +4 more
doaj   +2 more sources

Effects of Continuous Use of Oral Drospirenone/Estradiol on Lipid Profile, Body Weight, and BP in Females from Early Menopause

Journal of Pharmacy and Bioallied Sciences
Background: DRSP (drospirenone) is a progestin that has antiandrogenic and anti-mineralocorticoid activity. When used combined with estradiol (E2), drospirenone helps in relieving symptoms of menopause.
Roshan Mandloi, Shivangi Rajput, Bhavana Patel, Sarika Rawat, Sonu Rawat   +4 more
doaj   +2 more sources

Comparison of the lipophilicity parameters of drospirenone and lynestrenol [PDF]

Farmacja Polska, 2022
The aim of this study was the chromatographic analysis of two steroid compounds; drospirenone and lynestrenol, representing the group of pro- and gestagens, respectively, and its application to determine the lipophilicity parameters of both these ...
Agnieszka Kusztal, Małgorzata Dołowy, Katarzyna Bober-Majnusz   +2 more
doaj   +1 more source

Evaluating the Cognitive Impacts of Drospirenone, a Spironolactone-Derived Progestin, Independently and in Combination With Ethinyl Estradiol in Ovariectomized Adult Rats

Frontiers in Neuroscience, 2022
Oral contraceptives and hormone therapies require a progestogen component to prevent ovulation, curtail uterine hyperplasia, and reduce gynecological cancer risk.
Stephanie V. Koebele, Stephanie V. Koebele, Mallori L. Poisson, Mallori L. Poisson, Justin M. Palmer, Justin M. Palmer, Claire Berns-Leone, Claire Berns-Leone, Steven N. Northup-Smith, Steven N. Northup-Smith, Veronica L. Peña, Veronica L. Peña, Isabel M. Strouse, Isabel M. Strouse, Haidyn L. Bulen, Haidyn L. Bulen, Shruti Patel, Shruti Patel, Corissa Croft, Corissa Croft, Heather A. Bimonte-Nelson, Heather A. Bimonte-Nelson   +21 more
doaj   +1 more source

High risk oral contraceptive hormones do not directly enhance endothelial cell procoagulant activity in vitro

PLoS ONE, 2023
Background Oral contraceptive (OC) use increases venous thromboembolism risk 2-5-fold. Procoagulant changes can be detected in plasma from OC users even without thrombosis, but cellular mechanisms that provoke thrombosis have not been identified ...
Emma G. Bouck, Marios Arvanitis, William O. Osburn, Yaqiu Sang, Paula Reventun, Homa K. Ahmadzia, Nicholas L. Smith, Charles J. Lowenstein, Alisa S. Wolberg   +8 more
doaj   +2 more sources

Post-abortion contraception: how to make the right choice?

Гинекология, 2021
More than 600 thousands abortions are performed annually in Russia. Women presenting for abortion care are often motivated by the pregnancy to use effective contraception; they are also at high risk for repeat unintended pregnancy.
Yuliya E. Dobrokhotova, Metanat R. Narimanova, Svetlana A. Khlynova, Liudmila V. Saprykina, Irina Iu. Il’ina   +4 more
doaj   +1 more source

A single-arm study to evaluate the transfer of drospirenone to breast milk after reaching steady state, following oral administration of 4 mg drospirenone in healthy lactating female volunteers

Women's Health, 2020
Objective: The primary objective of this trial was to assess the transfer of drospirenone to breast milk after daily administration of an oral test preparation containing 4 mg of drospirenone at the steady state.
Dace Melka, Kalev Kask, Enrico Colli, Pedro-Antonio Regidor   +3 more
doaj   +1 more source