The benefits of estetrol addition to drospirenone for contraception [PDF]
AJOG Global Reports, 2023 Ethinylestradiol and drospirenone combined oral contraceptive formulations have been marketed for >20 years. Drospirenone has antimineralocorticoid and anti-androgenic effects that may offer several health benefits.
Jean Michel Foidart, PhD, MD +5 more
doaj +2 more sources
A concept for a new approach to combined oral contraception from adolescence to perimenopause: Continuous use of the oral GnRH antagonist Relugolix and the fetal estrogen Estetrol [PDF]
Acta Obstetricia et Gynecologica ScandinavicaThe introduction of oral GnRH antagonists has created the possibility to replace progestins in combined oral contraceptives as the suppressor of ovarian function.
Herjan J. T. Coelingh Bennink +9 more
doaj +2 more sources
Structure and Thermal Stability of Two Estetrol Solvates
Crystals, 2023 Two solvates of estetrol have been isolated and characterized by SCXRD and PXRD as well as by thermal analyses, morphology and spectroscopy. Estetrol monohydrate (Estetrol.H2O, S.G.
Magda Monari +2 more
exaly +3 more sources
Estetrol‐based combined oral contraceptives: A systematic review of clinical outcomes [PDF]
Acta Obstetricia et Gynecologica ScandinavicaIntroduction Combined oral contraceptive pills (COCs) are a common contraceptive method among women of reproductive age. Ethinylestradiol (EE) is a frequently used estrogen component in COCs.
Mathilde Råberg +3 more
doaj +2 more sources
Delayed start of estetrol drospirenone versus ethinyl estradiol gestodene for ovulation inhibition in a noninferiority randomized controlled trial [PDF]
Scientific ReportsDelayed-start contraception may reduce the risk of unintended pregnancy; however, data on newer formulations, such as estetrol (E4)-containing pills are limited.
Sirarat Ittipuripat +6 more
doaj +2 more sources
Estetrol Inhibits Endometriosis Development in an In Vivo Murine Model [PDF]
BiomoleculesEndometriosis is characterized by the growth of endometrial-like tissue outside the uterus, and it is associated with alterations in the expression of hormone receptors and inflammation.
Ana Sofia Zabala +8 more
doaj +2 more sources
EMBO Molecular Medicine, 2014 Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E2) and E4 are very similar, as well ...
Coralie Fontaine +2 more
exaly +2 more sources
Impact of estetrol and drospirenone combination therapy on alleviation of the pelvic pain of endometriosis: a randomized control trial [PDF]
F&S ReportsObjective: To study the impact of estetrol (E4), a novel native estrogen with selective tissue activity, on endometriosis-associated pelvic pain (EAPP) and global impressions of endometriosis pain.
Tasuku Harada, M.D., Ph.D. +6 more
doaj +2 more sources
Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer’s Disease [PDF]
CellsMitochondrial dysfunction is an early driver of Alzheimer’s disease (AD), and the decline in sex hormones, including 17β-estradiol (E2), at menopause has been linked to AD risk in women. While E2 exerts potent neuroprotective and mitochondrial-regulatory
Amandine Grimm +7 more
doaj +2 more sources
Estetrol: a new estrogen component in combined oral contraceptives: A review [PDF]
Гинекология, 2023 Estetrol (E4) is a steroid hormone found in the urine of pregnant women in 1965. E4 is produced only during pregnancy and enters the maternal bloodstream through the placenta.
Aida U. Hamadyanova +7 more
doaj +1 more source