Results 31 to 40 of about 805 (190)

Low thrombin generation in users of a contraceptive containing estetrol and drospirenone [PDF]

, 2022
OBJECTIVE: To compare the impact on thrombin generation of the new combined oral contraceptive containing 15 mg estetrol and 3 mg drospirenone with ethinylestradiol (30 or 20 mcg) associated either with 150 mcg levonorgestrel or with 3 mg drospirenone ...
Jost, Maud, Foidart, Jean Michel, Gaspard, Ulysse, Foidart, Jean-Michel, Douxfils, Jonathan, Douxfils, Jonathan; id_orcid, Morimont, Laure, Dogné, Jean-Michel   +7 more
core   +1 more source

The rediscovery of estetrol and its implications for estrogen treatment. [PDF]

Menopause
Objectives: To summarize the literature on the rediscovery and clinical exploration of the fourth natural estrogen estetrol (E4), more than 100 years after the discovery of estrone (E1), estradiol (E2), and estriol (E3).
Coelingh Bennink HJT, Gosden R, Stanczyk FZ, Adashi EY.   +3 more
europepmc   +3 more sources

Vasorelaxing effects of estetrol in rat arteries [PDF]

Journal of Endocrinology, 2012
This study comparedex vivorelaxing responses to the naturally occurring human hormone estetrol (E4) vs 17β-estradiol (E2) in eight different vascular beds. Arteries were mounted in a myograph, contracted with either phenylephrine or serotonin, and cumulative concentration-response curves (CRCs) to E4and E2(0.1–100 μmol/l) were constructed.
Rob H P, Hilgers, Suzanne, Oparil, Wout, Wouters, Herjan J T, Coelingh Bennink   +3 more
openaire   +2 more sources

Oral Drospirenone/Estetrol as Rapid and Random Start Endometrial Preparation before Office Hysteroscopic Polypectomy: A Multicenter, Prospective, Randomized Controlled Trial.

Gynecol Obstet Invest
Objectives: Endometrial preparation provides significant surgical benefits prior to hysteroscopic procedures. However, there is still no consensus on the optimal presurgical protocol.
Etrusco A, Agrifoglio V, Chiantera V, Russo G, Golia D Apos Augè T, Monti M, Giannini A, Riemma G, Scibilia G, Pecorino B, D'Amato A, Laganà AS.   +11 more
europepmc   +2 more sources

Estetrol Increases Progesterone Genetic Response without Triggering Common Estrogenic Effects in Endometriotic Cell Lines and Primary Cultures

Biomedicines, 2023
Estetrol (E4), a natural estrogen produced by the human fetal liver, is actively studied for menopause and breast cancer treatment. It has low side effects and preferential estrogen receptor alpha (ERα) affinity.
Daniel Patiño-García, Jaime Palomino, Cristián Pomés, Claudia Celle, Verónica Torres-Estay, Renán Orellana   +5 more
doaj   +1 more source

Estetrol combined to progestogen for menopause or contraception indication is neutral on breast cancer [PDF]

, 2021
peer reviewedHormonal treatments, especially those used to treat menopause symptoms are known to increase breast cancer risk. It is thus necessary to identify new formulations with a better benefit/risk pro-file.
Céline Gérard, Erik Maquoi, Maquoi, Erik, Françoise Lenfant, Elisabetta Marangoni, Joiret, Marc, Erika Konradowski, Mélanie Taziaux, Houtman, René, Sounni, Nor Eddine, Geris, Liesbet, Anne Gallez, Gérard, Céline, Primac, Irina, Marc Joiret, Silvia Blacher, Jean-Michel Foidart, Foidart, Jean-Michel, Lenfant, Françoise, Gallez, Anne, Taziaux, Mélanie, Irina Primac, Liesbet Geris, Marangoni, Elisabetta, René Houtman, Nor Eddine Sounni, Noël, Agnès, Agnès Noël, Konradowski, Erika, Christel Péqueux, Blacher, Silvia, Pequeux, Christel   +31 more
core   +1 more source

Neuroprotective effects of estetrol in combined oral contraceptives: A review

Гинекология, 2023
One of the most effective contraception methods is combined hormonal contraceptives. According to the current prescribing information, in addition to their primary effect, they have several concomitant positive effects on the female body non ...
Mekan R. Orazov, Vasily V. Ermakov, Dmitrii S. Novginov   +2 more
doaj   +1 more source

Safety and Efficacy of a 24-Cycle Administration of a Drospirenone-Only Pill in Japanese Women. [PDF]

J Obstet Gynaecol Res
ABSTRACT Aim We conducted a 24‐cycle study to evaluate long‐term safety of 4 mg of drospirenone (DRSP), a progestin‐only pill (POP), for contraception in Japanese women. Methods A multicenter, single‐arm 24‐cycle study was conducted in women who participated in the 13 cycle study of DRSP.
Kitamura K, Colli E, Kikuyama R, Kurihara Y, Azuma R, Kagawa T.   +5 more
europepmc   +2 more sources

Adipocyte regulation of cancer stem cells

Cancer Science, Volume 114, Issue 11, Page 4134-4144, November 2023., 2023
Schematic illustration of the multiple mechanisms involved in the upregulation of cancer stem cell properties by adipocytes. Abstract Cancer stem cells (CSCs) are a highly tumorigenic subpopulation of the cancer cells within a tumor that drive tumor initiation, progression, and therapy resistance.
Behnoush Khaledian, Lisa Thibes, Yohei Shimono   +2 more
wiley   +1 more source

Prospects for hormonal contraception in patients with breast diseases: the Mona Lisa smile effect. A review

Гинекология, 2023
Breast diseases (BD) are among the most urgent issues of modern reproductive medicine. This organ is an integral part of the female reproductive system and undergoes cyclic changes during the menstrual cycle.
Mekan R. Orazov, Viktor E. Radzinskiy, Evgeny D. Dolgov   +2 more
doaj   +1 more source