Results 11 to 20 of about 805 (190)

The estetrol-drospirenone-containing contraceptive as a drug of choice for patients with mastalgia

Клинический разбор в общей медицине, 2023
The problem of mastalgia is widespread: up to 70% of women report regular or episodic pain in the mammary gland. The role of benign breast disease in the occurrence of these complaints was noted only in 10–30% of cases, while in most women mastalgia is a
Mekan R. Orazov, Vasilii V. Ermakov
doaj   +2 more sources

Estetrol/Drospirenone: A Review in Oral Contraception

Drugs, 2022
Estetrol/drospirenone is a combined oral contraceptive (COC) with a plant-synthesised foetal oestrogen (estetrol) and a well-established progestin (drospirenone). In preclinical models, estetrol has lower binding affinity for the oestrogen receptor-α (ER-α) in contrast to estradiol and has antagonistic properties against membrane ER-α in several ...
Arnold Lee, Yahiya Y. Syed
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Estetrol: A New Choice for Contraception [PDF]

Journal of Clinical Medicine, 2021
Estetrol (E4) is a natural estrogenic steroid that is normally produced by human fetal liver. Recent research has demonstrated that it is a potent, orally bioavailable, natural selective estrogen receptor modulator; it has a moderate affinity for both human estrogen receptor alpha (ERα) and ERβ, with a preference for ERα.
Franca Fruzzetti, Tiziana Fidecicchi, Maria Magdalena Montt Guevara, Tommaso Simoncini   +3 more
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Estetrol and Mammary Gland: Friends or Foes? [PDF]

Journal of Mammary Gland Biology and Neoplasia, 2021
AbstractEstrogens have pleiotropic effects on many reproductive and non-reproductive tissues and organs including the mammary gland, uterus, ovaries, vagina, and endothelium. Estrogen receptor α functions as the principal mediator of estrogenic action in most of these tissues.
Gallez, Anne, Dias Da Silva, Isabelle, Wuidar, Vincent, Foidart, Jean-Michel, Pequeux, Christel   +4 more
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Pro-Apoptotic Effects of Estetrol on Long-Term Estrogen-Deprived Breast Cancer Cells and at Low Doses on Hormone-Sensitive Cells

Breast Cancer: Basic and Clinical Research, 2019
Purpose: Postmenopausal women with estrogen receptor-positive breast cancers often respond initially to tamoxifen or aromatase inhibitor therapy. Resistance to these treatments usually develops within 12 to 18 months.
Wei Yue, Carole Verhoeven, Herjan Coelingh Bernnink, Ji-ping Wang, Richard J Santen   +4 more
doaj   +2 more sources

Estetrol and Its Effects on the Damaged Brain

, 2019
Estrogens play an important role not only in the reproductive system but in the central nervous system as well. Major events of ontogenesis that occur earlier in pregnancy are connected to the formation of estrogen receptors and expression of estrogens leading to the normal physiological development of the central nervous system, though development of ...
Tskitishvili, Ekaterine, Foidart, Jean-Michel   +1 more
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Aplicaciones y efectos del estetrol en la práctica ginecológica

Universidad Médica Pinareña
Este estudio abarca información sobre el estetrol (E4), el mismo que es un estrógeno endógeno sintetizado exclusivamente por el hígado fetal durante la gestación, alcanzando concentraciones significativas en la circulación materna a través del ...
Sylvia del Pilar Nuñez Arroba, Daniela Monserrath Ocaña Viera , Ariana Nicole Erazo Mesías , Michelle Patricia Sanisaca Lema   +3 more
doaj   +2 more sources

Effect of estetrol on Beta-Endorphin level in female rats

Steroids, 2015
Estetrol (E4), a naturally occurring estrogen produced exclusively by human fetal liver, is currently being evaluated for potential use in contraception and menopausal care in humans. The present study was designed to profile E4 effects on the central nervous system, to assess the in vivo effects of E4 administration on Beta-Endorphin (β-END) release ...
Pluchino, Nicola, Drakopoulos, Panagiotis, Casarosa, E, Freschi, L, Petignat, Patrick, Yaron, Michal, Genazzani, A R   +6 more
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Low thrombin generation in postmenopausal women using estetrol [PDF]

Climacteric
Estetrol (E4) represents a novel estrogen of interest to relieve vasomotor symptoms. E4 activates the nuclear estrogen receptor α (ERα) but antagonizes the estradiol ERα-dependent membrane-initiated steroid signaling pathway. The distinct pharmacological properties of E4 could explain its low impact on hemostasis.
Morimont, L, Didembourg, M, Bouvy, C, Jost, M, Taziaux, M, Oligschlager, Y, van Rooijen, M, Gaspard, Ulysse, Foidart, Jean-Michel, Douxfils, J   +9 more
core   +5 more sources

Un nuevo estrógeno: estetrol [PDF]

A nivel mundial se ha aprobado un nuevo anticonceptivo oral combinado que utiliza estetrol (E4), un tipo de estrógeno con un perfil farmacológico novedoso y selectivo en diferentes tejidos. Aunque el estetrol fue descubierto en los años 60, su uso como anticonceptivo fue aprobado en 2020 tras estudios que demostraron su eficacia y un perfil de ...
Viroga, Stephanie
openaire   +2 more sources