Results 21 to 30 of about 805 (190)

Estetrol modulates endothelial nitric oxide synthesis in human endothelial cells [PDF]

Frontiers in Endocrinology, 2015
Estetrol (E4) is a natural human estrogen that is present at high concentrations during pregnancy. E4 has been reported to act as an endogenous estrogen receptor modulator, exerting estrogenic actions on the endometrium or the central nervous system but ...
Maria Magdalena eMontt-Guevara, Maria Silvia eGiretti, Eleonora eRusso, Andrea eGiannini, Paolo eMannella, Andrea Riccardo Genazzani, Alessandro David Genazzani, Tommaso eSimoncini   +7 more
doaj   +2 more sources

Estetrol, un estrógeno endógeno de acción específica de tejido

Revista Chilena de Obstetricia y Ginecología
El estetrol (E4) es un estrógeno endógeno sintetizado por el hígado fetal. A diferencia de los otros estrógenos, posee una actividad tisular selectiva, actuando principalmente en los receptores nucleares α sin actividad sobre los receptores de membrana ...
Marcelo Bianchi-Poblete, Eduardo Correa-Allende   +1 more
doaj   +2 more sources

Post Hoc Analysis of a Previous Study of Estetrol 15 mg/Drospirenone 3 mg Combination for Dysmenorrhea and Uterine Bleeding in Adenomyosis Patients. [PDF]

Reprod Med Biol
ABSTRACT Purpose To clarify the efficacy and safety of the estetrol 15 mg/drospirenone 3 mg combination among Japanese women with adenomyosis by post hoc analyses of a previous randomized clinical study. Methods Post hoc analyses were performed using data from a 16‐week, multi‐center, randomized, double‐blinded, placebo‐controlled, parallel‐group study,
Harada T, Kobayashi T, Koga E, Nogami M, Sasahara A, Takayanagi T, Hirayama M, Osuga Y.   +7 more
europepmc   +2 more sources

Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells [PDF]

Journal of Translational Medicine
Background Estetrol (E4) is a natural estrogen produced by the fetal liver during pregnancy. Due to its favorable safety profile, E4 was recently approved as estrogenic component of a new combined oral contraceptive.
Francesca Cirillo, Asia Spinelli, Marianna Talia, Domenica Scordamaglia, Maria Francesca Santolla, Fedora Grande, Bruno Rizzuti, Marcello Maggiolini, Céline Gérard, Rosamaria Lappano   +9 more
doaj   +2 more sources

Impact of combined oral contraceptives and progestin-only pills on psychological and sexual well-being of women with endometriosis: A systematic review. [PDF]

Acta Obstet Gynecol Scand
Hormonal treatments for endometriosis (combined oral contraceptives/progestin‐only pills) do not show increased psychological or sexual risks compared with placebo. When pain is effectively controlled, these therapies appear well tolerated and may improve overall well‐being.
Salmeri N, Piccini M, Caprara F, Somigliana E, Viganò P, Vercellini P.   +5 more
europepmc   +2 more sources

Lachnospiraceae-Derived Extracellular Vesicles Mediate the Cardioprotective Effects of Barley Leaf in Myocardial Infarction by Improving Intestinal Stem Cell Function. [PDF]

J Extracell Vesicles
ABSTRACT Ischaemic cardiovascular diseases, particularly myocardial infarction (MI), remain the leading causes of morbidity and mortality worldwide. Targeting extracellular vesicles (EVs) from the gut microbiota by diet may provide opportunities to improve cardiovascular health. Barley leaf (BL) has a long history of use in Traditional Chinese medicine
Chen W, Zhao Y, Zhao Q, Zhou Y, Ma C, Dong L, Luo Y, Zhang Z, Chen F, Hu X, Li D.   +10 more
europepmc   +2 more sources

Effect of an estetrol/drospirenone contraceptive on sexual function in women of reproductive age [PDF]

Гинекология, 2023
The use of hormonal contraception is widespread worldwide. Over the years of use, it has been possible to study its contraceptive effectiveness and its effect on carbohydrate metabolism, blood coagulation, lipid profile, liver function tests, and other ...
Mekan R. Orazov, Vasily V. Ermakov, Dmitrii S. Novginov   +2 more
doaj   +1 more source

Body-identical estrogens in combined hormonal contraceptives: A safer path forward. [PDF]

Int J Gynaecol Obstet
International Journal of Gynecology &Obstetrics, Volume 172, Issue 1, Page 654-656, January 2026.
Chabbert-Buffet N, Diaz Yamal IJ, Douxfils J, Foidart JM, Fruzzetti F, Gemzell-Danielsson K, Nappi RE, Osuga Y, Descamps P.   +8 more
europepmc   +2 more sources

Pharmacological and metabolic effects of drospirenone as a progestin-only pill compared to combined formulations with estrogen

Women's Health, 2023
The spironolactone derivative drospirenone is combined with ethinylestradiol or estetrol in combined oral contraceptives. Formulations with 17-β-estradiol are used to treat climacteric symptoms.
Pedro-Antonio Regidor, Anna Mueller, Manuela Mayr   +2 more
doaj   +1 more source

Complex questions about combined hormonal contraception: A review

Гинекология, 2023
Combined oral contraceptives (COCs) containing synthetic analogs of sex steroids are considered the most effective and popular method of contraception worldwide.
Vera N. Prilepskaya, Lana L. Bostandzhian   +1 more
doaj   +1 more source