Results 141 to 150 of about 15,414 (282)

Cyclic Treatment With WIN 18,446, a Potential Male Contraceptive, is as Effective as Continuous Treatment for Suppression of Spermatogenesis in Mice

open access: yesAndrology, EarlyView.
ABSTRACT Background Retinoic acid plays a critical role in spermatogenesis during both spermatogonial differentiation and spermiation. Mice lacking enzymes that synthesize retinoic acid, Aldh1a1/1a2, in the testes are infertile. WIN 18,446 reversibly inhibits spermatogenesis by inhibiting ALDH1A1/1A2 and is a promising approach to male contraception ...
Jisun Paik   +3 more
wiley   +1 more source

Europe's contribution to the evaluation of the use of systemic antimicrobials in the treatment of periodontitis

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract This narrative review celebrates Europe's contribution to the current knowledge on systemically administered antimicrobials in periodontal treatment. Periodontitis is the most frequent chronic noncommunicable human disease. It is caused by dysbiotic bacterial biofilms and is commonly treated with subgingival instrumentation.
David Herrera   +4 more
wiley   +1 more source

An Overview of Endometriosis and Potential Pharmacogenetic Targets. [PDF]

open access: yesPharm Res
Pérez-Gómez N   +6 more
europepmc   +1 more source

Estetrol‐based combined oral contraceptives: A systematic review of clinical outcomes

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
This systematic review summarizes clinical outcomes of estetrol‐containing combined oral contraceptives, showing reliable contraceptive efficacy, predictable bleeding patterns, improved well‐being, and a favorable hemostatic and metabolic profile, suggesting a promising and potentially safer alternative to ethinylestradiol‐based formulations.
Mathilde Råberg   +3 more
wiley   +1 more source

Probiotic supplementation during pregnancy for vaginal microbiota improvement and pathogen clearance: A systematic review and meta‐analysis

open access: yesActa Obstetricia et Gynecologica Scandinavica, EarlyView.
Probiotic supplementation during pregnancy shows a modest, non‐robust increase in Group B Streptococcus decolonization, with no consistent benefit for bacterial vaginosis or vulvovaginal candidiasis. Probiotics may serve as a non‐antibiotic adjunct, but standardized regimens and ecological diagnostic frameworks are required.
Zimo Liu   +3 more
wiley   +1 more source

A rat model of oral hormonal contraception: Effects on drug preference and gonadal function. [PDF]

open access: yesBehav Neurosci
Vasquez A   +8 more
europepmc   +1 more source

Intravesical therapy for recurrent urinary tract infection: a systematic review and meta‐analysis

open access: yesBJU International, EarlyView.
Objective To undertake a systematic review and meta‐analysis to evaluate the efficacy, safety, and clinical applicability of intravesical instillations for preventing recurrent urinary tract infections (rUTIs). Methods PubMed/MEDLINE, Embase, Cochrane CENTRAL, Scopus, and Web of Science were searched from January 2000 to April 2025 for randomised and ...
Matthew Kwon   +3 more
wiley   +1 more source

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