Results 61 to 70 of about 15,414 (282)

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Synthetic estrogen and progestin effects on the myogenic program following damage in C2C12 murine myoblasts

Physiological Reports
Females exhibit distinct responses to exercise‐induced muscle damage, possibly due to circulating hormone profiles. Despite the widespread use of oral contraceptives (OC) among females, the muscle damage and repair response during synthetic hormone use ...
Mai Wageh, Michael Kamal, Gianni Parise
doaj   +1 more source

Low adaptive potential for tolerance to ethynylestradiol, but also low toxicity, in a grayling population (Thymallus thymallus)

BMC Evolutionary Biology, 2019
Background The presence of a novel pollutant can induce rapid evolution if there is additive genetic variance for the tolerance to the stressor. Continuous selection over some generations can then reduce the toxicity of the pollutant but also deplete the
Lucas Marques da Cunha, Diane Maitre, Claus Wedekind   +2 more
doaj   +1 more source

A perspective on current research investigating the effects of hormonal contraceptives on determinants of female athlete performance [PDF]

, 2016
Hormonal contraceptives are used by approximately half of female athletes and may affect athletic performance as a result of their action on the endogenous hormonal milieu.
Elliott-Sale, K, Martin, D
core   +3 more sources

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Effects of Progesterone and Its Antagonist Mifepristone on Progesterone Receptor A Expression in Human Umbilical Vein Endothelial Cells [PDF]

, 2009
Effects of female steroid hormones on endothelial cells are gaining increased importance due to several studies on the effects of hormonal treatment on cardiovascular risk.
Friese, Klaus, Jeschke, Udo, Kuhn, Christina, Ochsenkühn, Robert, Scholz, Christoph, Schulze, Sandra, Toth, Bettina   +6 more
core   +1 more source

Therapy for Myhre Syndrome: Goals, Misconceptions, and Current Agents

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre Syndrome (MYHRS, MIM #139210) is a rare, multisystem connective tissue disorder caused by recurrent heterozygous gain‐of‐function pathogenic variants in the SMAD4 gene, a key player in TGF‐β signaling and a regulator of extracellular matrix homeostasis.
Alessandro De Falco, Alfonso Manuel D'Alessio, Nicola Brunetti‐Pierri   +2 more
wiley   +1 more source

Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors [PDF]

, 2018
Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant.
Codacci-Pisanelli, G, Del Pup, L, Levi-Setti, P E, Patrizio, P, Peccatori, F A   +4 more
core   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

No additive genetic variance for tolerance to ethynylestradiol exposure in natural populations of brown trout (Salmo trutta)

Evolutionary Applications, 2019
One of the most common and potent pollutants of freshwater habitats is 17‐alpha‐ethynylestradiol (EE2), a synthetic component of oral contraceptives that is not completely eliminated during sewage treatment and that threatens natural populations of fish.
Lucas Marques da Cunha, Anshu Uppal, Emily Seddon, David Nusbaumer, Etienne L.M. Vermeirssen, Claus Wedekind   +5 more
doaj   +1 more source