Results 71 to 80 of about 15,414 (282)

Provisional Dynamic Hinged External Fixation Enables Arthroscopy‐Assisted Circular Frame Reconstruction of Complex Tibial Plateau Fractures

open access: yesArthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To describe the surgical technique and early operative outcomes of using a provisional dynamic external fixator to facilitate arthroscopic‐assisted reduction of complex tibial plateau fractures. Methods Between 2014 and 2024, we conducted a retrospective single‐center case series of Schatzker IV‐VI tibial plateau fractures treated with ...
Ilan Y. Mitchnik   +7 more
wiley   +1 more source

POLYCYSTIC OVARIAN SYNDROME

open access: yesАкушерство, гинекология и репродукция, 2016
Polycystic ovarian syndrome (PCOS) is a rather common disease which represents one of the most topical issues of gynecological endocrinology. This review article presents modern data on etiology and pathogenesis of PCOS and provides substantiation for ...
T. D. Guriev
doaj  

Children's Health Spending: 2010-2014 [PDF]

open access: yes, 2016
Children's Health Spending: 2010-2014 examines spending on health care for children covered by employer-sponsored insurance from 2010 to 2014. For the first time, HCCI analyzed children's health care spending trends at the state level, reporting on ...

core  

Prescribing of Medication to Prevent Glucocorticoid Harms in Patients With Polymyalgia Rheumatica: A Cross‐Sectional Study and Two Emulated Target Trials in the Clinical Practice Research Datalink Aurum

open access: yesArthritis &Rheumatology, EarlyView.
Objective Polymyalgia rheumatica (PMR) is a common indication for long‐term glucocorticoid (GC) treatment. Bone‐protective and gastroprotective medications are recommended for those at high risk of adverse events from GCs, but no trials have evaluated their effectiveness in PMR.
Helen Twohig   +5 more
wiley   +1 more source

Transaminase Enzyme and Liver Histological Profile of Mice Administered Extract of Pegagan (Centella Asiatica (L.) Urban) [PDF]

open access: yes, 2011
The purpose of this study was to determine whether pegagan caused toxic effects on the liver. This study used completely randomized design with four treatments, ie 125, 200, 275 mg/kg BW and control, each treatment consisting of six replicates. Variables
Adi, T. T. (T)   +2 more
core  

The quantitative impact of metabolism‐inhibiting drugs on the occurrence of adverse drug reactions—A backward selection approach

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Aim The quantitative effect of several inhibitory drugs on the development of adverse drug reactions (ADRs) is currently difficult to estimate. Our aim was to identify metabolic pathways, which, when inhibited, increase the risk for certain ADRs, and to use this system to consider comedication at individual level. Methods Data of a prospective
Judith Berres   +8 more
wiley   +1 more source

Oral contraceptive progestins and angiotensin-dependent control of the renal circulation in humans [PDF]

open access: yes, 2014
Oral contraceptive (OC) use is associated with increased intra-renal renin-angiotensin-aldosterone system (RAA System) activity and risk of nephropathy, though the contribution of progestins contained in the OC in the regulation of angiotensin-dependent ...
Ahmed, Sofia B.   +3 more
core   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp   +6 more
wiley   +1 more source

Testing the affiliation hypothesis of homoerotic motivation in humans:the effects of progesterone and priming [PDF]

open access: yes, 2014
The frequency of homoerotic behavior among individuals who do not identify as having an exclusively homosexual sexual orientation suggests that such behavior potentially has adaptive value.
Cholakians, Argine Evelyn   +2 more
core   +2 more sources

Experimental studies on hepatocarcinogenesis by oral contraceptives, synthetic estrogen and progestogen, with special reference to the hormone dependency of the developed hepatocellular carcinoma.

open access: yesKanzo, 1986
経口避妊薬の肝発癌性,並びに発生した肝腫瘍のホルモン依存性を検索する目的で以下の研究を行った.生後4週齢のWistar/JCL雌ラットに硬性胃ゾンデを用いて毎日強制的に1年間にわたり下記の薬剤を1日1回投与した.I群:ethinylestradiol 0.075mg+norethindrone acetate 6mg in 0.5ml olive oil, II群:I群の倍量.III群・IV群:I群及びII群の対照としてolive oilのみをそれぞれ0.5mlまたは1.0ml.薬剤投与終了の時点で,対照としたIII群及びIV群では全く腫瘍の発生を認めなかったが,I群:38匹中6匹(15.8%),II群:27匹中6匹(22.2%)に高分化型肝細胞癌の発生を認めた.ついでホルモンの投与を中止したところ,
openaire   +2 more sources

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