Identification of contractile vacuole proteins in Trypanosoma cruzi. [PDF]
PLoS ONE, 2011 Contractile vacuole complexes are critical components of cell volume regulation and have been shown to have other functional roles in several free-living protists.
Paul N Ulrich +11 more
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The Polarized Redistribution of the Contractile Vacuole to the Rear of the Cell is Critical for Streaming and is Regulated by PI(4,5)P2-Mediated Exocytosis [PDF]
Frontiers in Cell and Developmental Biology, 2022 Dictyostelium discoideum amoebae align in a head to tail manner during the process of streaming during fruiting body formation. The chemoattractant cAMP is the chemoattractant regulating cell migration during this process and is released from the rear of
Sana A. Fadil +4 more
doaj +3 more sources
The C Isoform of Dictyostelium Tetraspanins Localizes to the Contractile Vacuole and Contributes to Resistance against Osmotic Stress. [PDF]
PLoS ONE, 2016 Tetraspanins (Tsps) are membrane proteins that are widely expressed in eukaryotic organisms. Only recently, Tsps have started to acquire relevance as potential new drug targets as they contribute, via protein-protein interactions, to numerous ...
Tineke Albers +3 more
doaj +3 more sources
Rab11 regulates trafficking of trans-sialidase to the plasma membrane through the contractile vacuole complex of Trypanosoma cruzi. [PDF]
PLoS Pathogens, 2014 Trypanosoma cruzi is the etiologic agent of Chagas disease. Although this is not a free-living organism it has conserved a contractile vacuole complex (CVC) to regulate its osmolarity.
Sayantanee Niyogi +3 more
doaj +3 more sources
The old and the new about the contractile vacuole of Trypanosoma cruzi. [PDF]
J Eukaryot Microbiol, 2022 Osmoregulation is a conserved cellular process required for the survival of all organisms. In protists, the need for robust compensatory mechanisms that can maintain cell volume and tonicity within physiological range is even more relevant, as their life
Jimenez V, Miranda K, Augusto I.
europepmc +2 more sources
Structure and dynamics of the contractile vacuole complex in Tetrahymena thermophila.
J Cell Sci, 2023 The contractile vacuole complex (CVC) is a dynamic and morphologically complex membrane organelle, comprised of a large vesicle (bladder) linked with a tubular reticulum (spongiome).
Cheng CY +4 more
europepmc +2 more sources
The contractile vacuole as a key regulator of cellular water flow in Chlamydomonas reinhardtii. [PDF]
Eukaryot Cell, 2014 Most freshwater flagellates use contractile vacuoles (CVs) to expel excess water. We have used Chlamydomonas reinhardtii as a green model system to investigate CV function during adaptation to osmotic changes in culture medium.
Komsic-Buchmann K +2 more
europepmc +2 more sources
Quantitative assessment of the nanoanatomy of the contractile vacuole complex in <i>Trypanosoma cruzi</i>. [PDF]
Life Sci AllianceElectron microscopy analysis of the osmoregulatory system in T. cruzi cell lines subjected to cryopreparation methods revealed dynamic changes in the contractile vacuole complex (CVC) and the structure of the adhesion plaque domain during the CVC ...
Augusto I +7 more
europepmc +2 more sources
Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole. [PDF]
Mol Biol Cell, 2012 A molecular dissection of contractile vacuole (CV) discharge shows that Rab8a is recruited to the CV a few seconds before the exocyst. Together they tether it to the plasma membrane and commit it to fusion.
Essid M +4 more
europepmc +2 more sources
Regulation of contractile vacuole formation and activity in Dictyostelium. [PDF]
EMBO J, 2008 The contractile vacuole (CV) system is the osmoregulatory organelle required for survival for many free-living cells under hypotonic conditions. We identified a new CV regulator, Disgorgin, a TBC-domain-containing protein, which translocates to the CV membrane at the late stage of CV charging and regulates CV-plasma membrane fusion and discharging ...
Du F +6 more
europepmc +4 more sources