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VacQuant: a tool to quantify neurodegeneration and associated vacuolation in brain tissue [PDF]
FlyNeurodegenerative diseases are devastating conditions characterized by progressive cognitive decline with few available treatments. Neurodegeneration can be quantified in vertebrate and invertebrate models of disease by analysis of vacuolation – the ...
Kate L. Jordan +3 more
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Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche
mBio, 2022 Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation leads to CCV acidification and bacterial death.
Tatiana M. Clemente +6 more
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Idiosyncratic Biogenesis of Intracellular Pathogens-Containing Vacuoles
Frontiers in Cellular and Infection Microbiology, 2021 While most bacterial species taken up by macrophages are degraded through processing of the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway, intravacuolar pathogens have evolved to evade degradation through the endosomal ...
Bethany Vaughn +2 more
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In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts
Molecules, 2022 Although Erythrina senegalensis is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date.
Souleymane Fofana +7 more
doaj +1 more source
Yeast Morphology Assessment through Automated Image Analysis during Fermentation
Fermentation, 2021 The kinetics and success of an industrial fermentation are dependent upon the health of the microorganism(s) responsible. Saccharomyces sp. are the most commonly used organisms in food and beverage production; consequently, many metrics of yeast health ...
Mario Guadalupe-Daqui +3 more
doaj +1 more source
Viruses, 2020 Polyomaviruses are a family of small, non-enveloped DNA viruses that can cause severe disease in immunosuppressed individuals. Studies with SV40, a well-studied model polyomavirus, have revealed the role of host proteins in polyomavirus entry and ...
Nasim Motamedi +4 more
doaj +1 more source
mBio, 2022 Phosphoinositide lipids play key roles in a variety of processes in eukaryotic cells, but our understanding of their functions in the malaria parasite Plasmodium falciparum is still very much limited.
Angana Mukherjee +15 more
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Microbiology Spectrum, 2023 Antimicrobial peptides play an important role in human innate defense against microbial pathogens. LL-37 is the only member of the human cathelicidin family of antimicrobial peptides.
Sheng-Yuan Chen +2 more
doaj +1 more source
Pre-implantation mouse embryos cultured In vitro under different oxygen concentrations show altered ultrastructures [PDF]
, 2020 Assisted Reproductive Technologies routinely utilize different culture media and oxygen (O2) concentrations to culture human embryos. Overall, embryos cultured under physiological O2 tension (5%) have improved development compared to embryos cultured ...
Antonouli, S +6 more
core +1 more source
The guanine nucleotide exchange factor RIC8 regulates conidial germination through Gα proteins in Neurospora crassa. [PDF]
, 2012 Heterotrimeric G protein signaling is essential for normal hyphal growth in the filamentous fungus Neurospora crassa. We have previously demonstrated that the non-receptor guanine nucleotide exchange factor RIC8 acts upstream of the Gα proteins GNA-1 and
Borkovich, Katherine A +5 more
core +11 more sources