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VEXAS Syndrome for the laboratory physician: a case report [PDF]

Frontiers in Immunology
IntroductionVEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome represents a recently identified systemic condition, and its diagnosis and management carry significant clinical ramifications.
Chaoying Chen, Miaomiao Chen, Tieqiao Chen, Yong Chen, Lingzhi Liu, Yixi Zhu, Xiaoming Yi, Shuguang He   +7 more
doaj   +2 more sources

Protamine labeling with Reactive Black-5 and its molecularly designed derivatives visualize vacuoles in human sperm head [PDF]

Scientific Reports
To date, numerous studies have examined the etiological relationship between vacuoles and DNA fragmentation in human sperm, with vacuoles typically assessed using differential interference contrast microscopy.
Satoru Kaneko, Yukako Kuroda, Ami N. Saito, Moriaki Sakihara, Kazuya Inagaki, Junichiro Yamaguchi, Yuki Okada   +6 more
doaj   +2 more sources

Rimmed Vacuoles in Becker Muscular Dystrophy Have Similar Features with Inclusion Myopathies

PLoS ONE, 2012
Rimmed vacuoles in myofibers are thought to be due to the accumulation of autophagic vacuoles, and can be characteristic in certain myopathies with protein inclusions in myofibers.
Satoru Noguchi, May Christine V Malicdan, Yukiko K Hayashi   +2 more
exaly   +3 more sources

Coxiella burnetii Sterol-Modifying Protein Stmp1 Regulates Cholesterol in the Intracellular Niche

mBio, 2022
Coxiella burnetii replicates in a phagolysosome-like vacuole called the Coxiella-containing vacuole (CCV). While host cholesterol readily traffics to the CCV, cholesterol accumulation leads to CCV acidification and bacterial death.
Tatiana M. Clemente, Rochelle Ratnayake, Dhritiman Samanta, Leonardo Augusto, Paul A. Beare, Robert A. Heinzen, Stacey D. Gilk   +6 more
doaj   +1 more source

Idiosyncratic Biogenesis of Intracellular Pathogens-Containing Vacuoles

Frontiers in Cellular and Infection Microbiology, 2021
While most bacterial species taken up by macrophages are degraded through processing of the bacteria-containing vacuole through the endosomal-lysosomal degradation pathway, intravacuolar pathogens have evolved to evade degradation through the endosomal ...
Bethany Vaughn, Yousef Abu Kwaik, Yousef Abu Kwaik   +2 more
doaj   +1 more source

In Vitro Antioxidant and Anticancer Properties of Various E. senegalensis Extracts

Molecules, 2022
Although Erythrina senegalensis is a plant widely used in traditional medicine in sub-Saharan Africa, its biological properties have been poorly investigated to date.
Souleymane Fofana, Cédric Delporte, Rafaèle Calvo Esposito, Moussa Ouédraogo, Pierre Van Antwerpen, Innocent Pierre Guissou, Rasmané Semdé, Véronique Mathieu   +7 more
doaj   +1 more source

Yeast Morphology Assessment through Automated Image Analysis during Fermentation

Fermentation, 2021
The kinetics and success of an industrial fermentation are dependent upon the health of the microorganism(s) responsible. Saccharomyces sp. are the most commonly used organisms in food and beverage production; consequently, many metrics of yeast health ...
Mario Guadalupe-Daqui, Mandi Chen, Katherine A. Thompson-Witrick, Andrew J. MacIntosh   +3 more
doaj   +1 more source

SV40 Polyomavirus Activates the Ras-MAPK Signaling Pathway for Vacuolization, Cell Death, and Virus Release

Viruses, 2020
Polyomaviruses are a family of small, non-enveloped DNA viruses that can cause severe disease in immunosuppressed individuals. Studies with SV40, a well-studied model polyomavirus, have revealed the role of host proteins in polyomavirus entry and ...
Nasim Motamedi, Xaver Sewald, Yong Luo, Walther Mothes, Daniel DiMaio   +4 more
doaj   +1 more source

A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum

mBio, 2022
Phosphoinositide lipids play key roles in a variety of processes in eukaryotic cells, but our understanding of their functions in the malaria parasite Plasmodium falciparum is still very much limited.
Angana Mukherjee, Marie-Ève Crochetière, Audrey Sergerie, Souad Amiar, L. Alexa Thompson, Zeinab Ebrahimzadeh, Dominic Gagnon, Florian Lauruol, Alexandra Bourgeois, Thomas Galaup, Stéphanie Roucheray, Stéphanie Hallée, Prasad K. Padmanabhan, Robert V. Stahelin, Joel B. Dacks, Dave Richard   +15 more
doaj   +1 more source

Antimicrobial peptide LL-37 disrupts plasma membrane and calcium homeostasis in Candida albicans via the Rim101 pathway

Microbiology Spectrum, 2023
Antimicrobial peptides play an important role in human innate defense against microbial pathogens. LL-37 is the only member of the human cathelicidin family of antimicrobial peptides.
Sheng-Yuan Chen, Che-Kang Chang, Chung-Yu Lan   +2 more
doaj   +1 more source