Results 21 to 30 of about 99,892 (263)

Anti-inflammatory effects of yeast-derived vacuoles on LPS-induced murine macrophage activation

Microbiology Spectrum, 2023
Saccharomyces cerevisiae is a single-celled fungal microorganism. S. cerevisiae-derived vacuoles are closely related to mammalian lysosomes, which play a role in the degradation of macromolecules by various hydrolytic enzymes.
Su-Min Lee, Yang-Hoon Kim, Jiho Min
doaj   +1 more source

The influence of osmotic stress on the content of calcium ions in the red beet vacuoles and on the transport activity of tonoplast proton pumps [PDF]

Journal of Stress Physiology & Biochemistry, 2012
The contents of calcium ions in the isolated vacuoles and in intact red beets under the conditions of dormancy and osmotic stress was determined. It is demonstrated that the content of calcium ions in the red beet vacuoles not exposed to osmotic stress ...
Ozolina N.V., E.V. Kolesnikova, V.N. Nurminsky, I.S. Nesterkina, L.V. Dudareva, T.I. Lapteva, R.K. Salyaev   +6 more
doaj  

Vacuoles in Bryophytes: Properties, Biogenesis, and Evolution

Frontiers in Plant Science, 2022
Vacuoles are the most conspicuous organelles in plants for their indispensable functions in cell expansion, solute storage, water balance, etc. Extensive studies on angiosperms have revealed that a set of conserved core molecular machineries orchestrate ...
Hao-ran Liu, Chao Shen, Danial Hassani, Wan-qi Fang, Zhi-yi Wang, Yi Lu, Rui-liang Zhu, Qiong Zhao, Qiong Zhao   +8 more
doaj   +1 more source

Pseudomonas aeruginosa utilizes the type III secreted toxin ExoS to avoid acidified compartments within epithelial cells. [PDF]

PLoS ONE, 2013
Invasive Pseudomonas aeruginosa (PA) can enter epithelial cells wherein they mediate formation of plasma membrane bleb-niches for intracellular compartmentalization.
Susan R Heimer, David J Evans, Michael E Stern, Joseph T Barbieri, Timothy Yahr, Suzanne M J Fleiszig   +5 more
doaj   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

VacQuant: a tool to quantify neurodegeneration and associated vacuolation in brain tissue

Fly
Neurodegenerative diseases are devastating conditions characterized by progressive cognitive decline with few available treatments. Neurodegeneration can be quantified in vertebrate and invertebrate models of disease by analysis of vacuolation – the ...
Kate L. Jordan, Colin D. Veal, Charalambos P. Kyriacou, Flaviano Giorgini   +3 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Soil to plant transfer of cadmium☆

Oilseeds and fats, crops and lipids
In soil, cadmium (Cd) is mainly adsorbed onto organic matter and iron hydroxides. Due to the difference in transmembrane electrochemical potential, the hydrated ions (Cd2+) present in the soil solution at the nanomolar level penetrate root cells.
Sterckeman Thibault
doaj   +1 more source

The entry of unclosed autophagosomes into vacuoles and its physiological relevance.

PLoS Genetics, 2022
It is widely stated in the literature that closed mature autophagosomes (APs) fuse with lysosomes/vacuoles during macroautophagy/autophagy. Previously, we showed that unclosed APs accumulated as clusters outside vacuoles in Vps21/Rab5 and ESCRT mutants ...
Zulin Wu, Haiqian Xu, Pei Wang, Ling Liu, Juan Cai, Yun Chen, Xiaomin Zhao, Xia You, Junze Liu, Xiangrui Guo, Tingting Xie, Jiajie Feng, Fan Zhou, Rui Li, Zhiping Xie, Yanhong Xue, Chuanhai Fu, Yongheng Liang   +17 more
doaj   +1 more source