Results 181 to 190 of about 254,999 (359)

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Effects of Phenylephrine Administration on the Circulatory Dynamics of Patients with Hypotension Due to Bleeding During Surgery, Specifically Left Ventricular End-Diastolic Volume, Effective Arterial Elastance, and Left Ventricular End-Systolic Elastance. [PDF]

J Clin Med
Shiraishi T, Sato M, Takagi R, Shigemi K, Matsuki Y.   +4 more
europepmc   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Contractile energy of RPE-1 cells on poly-acrylamide gels.

Carsten Alexander Baltes (22190513), Friederike Nolle (17009734), Kathi Michèle Kaiser (22190516), Erbara Gjana (22190519), Kristin Sander (22190522), Karin Jacobs (514419), Rhoda Joy Hawkins (22190525), Franziska Lautenschläger (131644)   +7 more
openalex   +1 more source

Longitudinal decline of lower extremity muscle power in healthy and mobility-limited older adults: influence of muscle mass, strength, composition, neuromuscular activation and single fiber contractile properties

, 2013
Kieran F. Reid, Evan Pasha, Gheorghe Doros, David J. Clark, Carolynn Patten, Edward M. Phillips, Walter R. Frontera, Roger A. Fielding   +7 more
openalex   +1 more source

Escherichia coli-Mediated Impairment of Ureteric Contractility Is Uropathogenic E. coli Specific [PDF]

, 2012
Rachel V. Floyd, Mathew Upton, S. J. Hultgren, Susan Wray, Theodor Burdyga, Craig Winstanley   +5 more
openalex   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

Advanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar, Marc A. Fernandez‐Yague, Adrien Bessaguet, Hosoowi Lee, Nicolas Giuseppone, Andrés J. García, Aránzazu del Campo   +6 more
wiley   +1 more source

Activation of the Anrep Effect in Aortic Stenosis Pre-TAVR and Post-TAVR: An Echocardiographic Pressure-Volume Analysis. [PDF]

JACC Adv
Reil JC, Sequeira V, Lucas P, Tadros L, Reil GH, Federspiel JM, Scholtz S, Omran H, Steendijk P, Marquetand C, Scholtz W, Piper C, Rudolph T, Rudolph V.   +13 more
europepmc   +1 more source

PIV-MyoMonitor: an accessible particle image velocimetry-based software tool for advanced contractility assessment of cardiac organoids [PDF]

Hae-yeon Lee, Bo Young Kim, Jiyue Yun, Jinseung Bae, Sungsu Park, Junseok Jeon, Hye Ryoun Jang, Jae-Cheol Lee, Soah Lee   +8 more
openalex   +1 more source

Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction [PDF]

, 2017
Evalynn Vasquez, Vivian Cristofaro, Stefan Lukianov, Fiona C. Burkhard, Ali Hashemi Gheinani, Katia Monastyrskaya, Diane R. Bielenberg, Meghan G. Sullivan, Rosalyn M. Adam   +8 more
openalex   +1 more source