Results 221 to 230 of about 217,710 (307)

Anrep Effect in the Right Ventricle: Evidence From Systolic Duration Analysis. [PDF]

J Am Heart Assoc
Reil JC, Sequeira V, Wink J, Federspiel JM, Reil GH, Steendijk P.   +5 more
europepmc   +1 more source

NUAK2 Inhibition Enhances Macromolecular Drug Delivery in a 3D Fibrotic Model of the Pancreatic Tumor Microenvironment

Advanced NanoBiomed Research, EarlyView.
Using a 3D cell culture model of the fibrotic barrier in pancreatic cancer, this work shows that inhibiting NUAK2 kinase in pancreatic stellate cells enhances macromolecular drug delivery. Mechanistically, NUAK2 inhibition disrupted actin stress fiber assembly to downregulate collagen I expression, thus enhancing macromolecular permeability.
Misaki Nakamura, Hiroyoshi Y. Tanaka, Mayu Ohira, Haruko Ohta‐Okano, Reika Nakamura, Yu Seno, Saaya Yara, Sakura Fujita, Daichi Shibata, Masaya Yamamoto, Shinichi Toyooka, Kensuke Osada, Horacio Cabral, Atsushi Masamune, Mitsunobu R. Kano   +14 more
wiley   +1 more source

Cytochrome P450-derived metabolites of docosahexaenoic acid or arachidonic acid enhance contractility of cultured rat cardiomyocytes: a pilot study. [PDF]

J Artif Organs
Kawakami H, Sato D, Sazuka M, Tsuchida S, Nishina A, Nakamura T, Kusunoki M, Tsutsumi K, Feng Z.   +8 more
europepmc   +1 more source

Impaired PIEZO1 function drives uterine hypercontractility in adenomyosis-associated dysmenorrhea. [PDF]

Hum Reprod Open
Yan D, Wang Y, Liu X, Guo SW.
europepmc   +1 more source

Correction: The rise of rat models for Duchenne muscular dystrophy and therapeutic evaluations. [PDF]

Skelet Muscle
Relaix F, Lafuste P, Taglietti V, Tiret L.   +3 more
europepmc   +1 more source

Functional anatomy, jaw mechanisms, and feeding behavior of Dunkleosteus terrelli (Placodermi, Arthrodira)

The Anatomical Record, EarlyView.
A new musculoskeletal reconstruction and revision of the cranio‐mandibular anatomy of the Devonian arthrodire placoderm Dunkleosteus terrelli from a comparative and functional anatomical perspective. Dunkleosteus is a specialized arthrodire with many specializations for feeding on large vertebrates, and many of its features are part of broader ...
Russell K. Engelman, Robert K. Carr, Kate Trinajstic, Zerina Johanson, Oleg A. Lebedev   +4 more
wiley   +1 more source

Cardiovascular phenotyping of children and adolescents with post-COVID syndrome (PCS) at initial diagnosis - a prospective observational single-center study. [PDF]

Front Cardiovasc Med
Hasan H, Hohmann D, Hysko K, Ibahrine S, Skeries V, Dold K, Pöhler GH, Wetzke M, Hansmann G.   +8 more
europepmc   +1 more source

Multi‐method analysis for the three‐dimensional reconstruction of muscle fascicles from DiceCT datasets

The Anatomical Record, EarlyView.
Abstract Muscle architecture is a major determinant of muscle performance and, in mammalian lineages, has been correlated with both feeding ecology and locomotor behaviors. Over the past decade, contrast‐enhanced micro‐CT (DiceCT) has emerged as an alternative to traditional dissection‐based measurement.
Aleksandra Ratkiewicz, Michael C. Granatosky, Cassidy E. Davis, Julia Molnar, Adam Hartstone‐Rose, Edwin Dickinson   +5 more
wiley   +1 more source

Exercise-induced out-of-proportion increase in afterload and impaired right ventricular contractile reserve in HFpEF. [PDF]

ESC Heart Fail
Wolter JS, Schulz A, Lange T, Kriechbaum SD, Kutty S, Kowallick JT, Treiber JM, Rolf A, Sossalla S, Hasenfuß G, Schuster A, Backhaus SJ.   +11 more
europepmc   +1 more source

Patterns of interspecific variation in labial microarchitecture among anthropoid primates and the evolution of the hominin lips

The Anatomical Record, EarlyView.
Comparative histological and semi‐automated image analysis of primate lips: Masson's trichrome‐stained sagittal sections were segmented to quantify the connective tissue, adipose, and muscular components, enabling interspecific comparisons of labial architecture.
Liat Rotenstreich, Kfir Eliyahu, Nir Edery, Lior Moss, Saleem Eben Bari, Assaf Marom   +5 more
wiley   +1 more source