Results 241 to 250 of about 254,999 (359)

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Ivabradine in acute care: Revisiting the funny current in critical care context. [PDF]

World J Crit Care Med
Mukesh A, Sharma A, Kothari N.
europepmc   +1 more source

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Twinfilin modulates tissue contractility through uncapping of capping protein in C. elegans. [PDF]

Development
Saini A, Kreizman S, Towsif E, Martinez-Lopez J, Zielonka IM, Nitzan A, Rudnick L, Shekhar S, Zaidel-Bar R.   +8 more
europepmc   +1 more source

MCP-1 gene transfer enhances intestinal muscle contractility during nematode infection

, 2003
Waliul I. Khan, Ashwin Varghese, Patricia Blennerhasset, Xianxi Huang, Jack Gauldie, Cory M. Hogaboam, Stephen M. Collins   +6 more
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

In vivo and ex vivo cardiovascular haemodynamic responses of preterm growth-restricted lambs to perinatal asphyxia. [PDF]

Clin Sci (Lond)
Azman Z, Piscopo BR, Sutherland AE, Thiel A, Zahra VA, Pham Y, Nitsos I, Hossain MM, Malhotra A, Miller SL, Bubb KJ, Polglase GR, Allison BJ.   +12 more
europepmc   +1 more source

Gravity‐Tolerant In‐Flight 3D Bioprinting Enabled by Stereolithography for Space Tissue Engineering

Advanced Science, EarlyView.
A flight‐compliant, closed stereolithographic 3D bioprinting system enables robust fabrication of acellular and cell‐laden hydrogel constructs under varying gravitational conditions, including microgravity and hypergravity phases. Printed structures retain dimensional fidelity and high‐resolution features, while cell viability remains high ...
Bianca Lemke, Matthias R. Kollert, Tobias Lam, Tobias Thiele, Nicolas Göbel, Lisa R. Köhn, Gabriela Korus, Lutz Kloke, Georg N. Duda   +8 more
wiley   +1 more source

Influence of bladder outlet obstruction on age-related changes in male bladder contractility. [PDF]

Investig Clin Urol
Choi JB, Cho KJ, Kim JC, Han YK, Ahn JH, Yang SJ, Koh JS.   +6 more
europepmc   +1 more source

Desmosomal Regulation of Gap Junction Dynamics and Cellular Contractility via Small GTPases: Implications for Cardiocutaneous Disease

, 2018
Chen Yuan Kam
openalex   +1 more source