Results 71 to 80 of about 1,499,696 (300)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Effects of Reward and Familiarity of Reward Agent on Spontaneous Play in Preschoolers: A Field Study

open access: yes, 1989
A field experiment was conducted with preschool children to test the effect of rewards on a familiar, spontaneous play activity, in conditions as close as possible to the children's natural school context, and to examine the role of familiarity of the ...
Paula Inez Cunha Gomide, Cesar Ades
core   +1 more source

A review of empirical evidence on different uncanny valley hypotheses: support for perceptual mismatch as one road to the valley of eeriness

open access: yesFrontiers in Psychology, 2015
The uncanny valley hypothesis, proposed already in the 1970s, suggests that almost but not fully humanlike artificial characters will trigger a profound sense of unease.
Jari eKätsyri   +3 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Do Recasts Provide Second Language Learners With Negative Evidence?

open access: yes, 2015
The purpose of this experimental study is to examine the effects of recasts on narrowing overgeneralized grammar in the second language (L2). The study involved testing three major hypotheses of the mechanisms underlying recasts: the direct contrast ...
Sakai, Hideki
core   +1 more source

The Survival of Contrastive Analysis Hypothesis: A Look Under the Hood

open access: yesTheory and Practice in Language Studies, 2022
The contrastive analysis hypothesis is one of the theories that has considerably impacted second language acquisition research. Since the 1970s, this theory, which had piqued the interest of both linguists and teachers, has been heavily criticised. It has been described as unrealistic and impractical, and its basic assumptions have been questioned and ...
openaire   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Contrast Agent Clearance Dynamics and Diffusion in the Mouse Brain After Ventricular Administration

open access: yesAdvanced Science
Fluid and solute exchange between cerebrospinal fluid (CSF) spaces and the central nervous system (CNS) parenchyma are critical for maintaining neural homeostasis and clearing metabolites.
Yann Decker   +2 more
doaj   +1 more source

A case of the Bayes factor in a comparative study according to gender of the fear of COVID-19 in Cuba

open access: yesRevista Cubana de Medicina Militar, 2021
A complementary analysis is reported using the Bayes Factor to contrast the statistical hypotheses of difference in a recent comparative study of fear of COVID-19 according to gender in Cuba, this methodological contribution allows quantifying the ...
Cristian Antony Ramos Vera
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

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