Results 81 to 90 of about 1,499,696 (300)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Influence of visually perceived shape and brightness on perceived size, expected weight, and perceived weight of 3D objects.

PLoS ONE, 2019
In the size-weight illusion, when two objects of identical weight but different volume are lifted, the smaller object is typically perceived to weigh more than the larger object. A well-known explanation for this and other weight illusions is provided by
Michele Vicovaro, Katia Ruta, Giulio Vidotto   +2 more
doaj   +1 more source

Fibromyalgia associated with repeated gadolinium contrast-enhanced MRI examinations

Radiology Case Reports, 2020
We report a case of a fibromyalgia (FM) patient with an history of brain-cancer presenting signs and symptoms of gadolinium toxicity following repeated administrations of a macrocyclic contrast agent, Gadovist.
Silvia Maria Lattanzio, PhD, Francesca Imbesi, MD   +1 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Contrasts in reasoning about omissions

, 2020
Omissions figure prominently in causal reasoning from diagnosis to ascriptions of negligence. One philosophical proposal posits that omissions are accompanied by a contrasting alternative that describes a case of orthodox (nonomissive) causation ...
Gordon Briggs, Sangeet Khemlani
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

What Does Visual Cortical Physiology of Neurotypical Populations Tell Us about the WCC and EPF Theories of Autism?

i-Perception, 2012
The signs of autism spectrum disorders (ASD)—lack of social communication, fixation, and repetitive action have to include visual perceptual abnormalities.
David P Crewther
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

P1-4: Neural Correlates of Fading Illusion Revealed in Responses of V1 Neurons

i-Perception, 2012
Visual stimuli without sharp edges fade gradually under visual fixation. This phenomenon is known as Troxler fading or fading illusion. Traditionally, this fading is explained by a hypothesis that physical stimulus is cancelled by a negative image ...
Kohei Kurihara, Kota S Sasaki, Izumi Ohzawa   +2 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source