Results 91 to 100 of about 3,277,772 (345)

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, Volume 599, Issue 7, Page 971-988, April 2025.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Balancing Robustness and Sensitivity using Feature Contrastive Learning [PDF]

open access: yesarXiv, 2021
It is generally believed that robust training of extremely large networks is critical to their success in real-world applications. However, when taken to the extreme, methods that promote robustness can hurt the model's sensitivity to rare or underrepresented patterns.
arxiv  

Can Centre Surround Model Explain the Enhancement of Visual Perception through Stochastic Resonance? [PDF]

open access: yesarXiv, 2010
We demonstrate the ability of centre surround model for simulating the enhancement of contrast sensitivity through stochastic resonance observed in psychophysical experiments. We also show that this model could be used to simulate the contrast sensitivity function through stochastic resonance.
arxiv  

Infrared Vertical External Cavity Surface Emitting Laser Threshold Magnetometer [PDF]

open access: yesAppl. Phys. Lett. 26 February 2024; 124 (9): 091110
Nitrogen-vacancy (NV) centers have considerable promise as high sensitivity magnetometers, however are commonly limited by inefficient collection and low contrasts. Laser threshold magnetometry (LTM) enables efficient collection and high contrasts, providing a path towards higher sensitivity magnetometry.
arxiv   +1 more source

Spatial contrast sensitivity of birds [PDF]

open access: yesJournal of Comparative Physiology A, 2006
Contrast sensitivity (CS) is the ability of the observer to discriminate between adjacent stimuli on the basis of their differences in relative luminosity (contrast) rather than their absolute luminances. In previous studies, using a narrow range of species, birds have been reported to have low contrast detection thresholds relative to mammals and ...
Mimi M. Ghim, William Hodos
openaire   +3 more sources

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, Volume 599, Issue 9, Page 1269-1284, May 2025.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

Improved Contrast Sensitivity DVS and its Application to Event-Driven Stereo Vision [PDF]

open access: yes, 2013
This paper presents a new DVS sensor with one order of magnitude improved contrast sensitivity over previous reported DVSs. This sensor has been applied to a bio-inspired event-based binocular system that performs 3D event-driven reconstruction of a ...
Benosman, Ryad B.   +5 more
core  

The critical sensor: a new type of evanescent wave immunosensor [PDF]

open access: yes, 1996
A new planar waveguide immunosensor has been developed in which adsorption at a surface, changing the refractive index contrast, is measured. In this ¿critical¿ sensor the change in the effective refractive index contrast is transducted to a shift of the
Borreman, A.   +3 more
core   +3 more sources

No sensitivity to functional forms in the Rosenzweig-MacArthur model with strong environmental stochasticity [PDF]

open access: yesarXiv, 2022
The classic Rosenzweig-MacArthur predator-prey model has been shown to exhibit, like other coupled nonlinear ordinary differential equations (ODEs) from ecology, worrying sensitivity to model structure. This sensitivity manifests as markedly different community dynamics arising from saturating functional responses with nearly identical shapes but ...
arxiv  

Distinct dysregulated pathways in sporadic and Lynch syndrome‐associated colorectal cancer offer insights for targeted treatment

open access: yesFEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.
This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause   +2 more
wiley   +1 more source

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