Results 81 to 90 of about 7,979,651 (342)

Circadian Rhythm of Contrast Sensitivity Is Regulated by a Dopamine–Neuronal PAS-Domain Protein 2–Adenylyl Cyclase 1 Signaling Pathway in Retinal Ganglion Cells

Journal of Neuroscience, 2013
Spatial variation in light intensity, called spatial contrast, comprises much of the visual information perceived by mammals, and the relative ability to detect contrast is referred to as contrast sensitivity (Purves et al., 2012).
Christopher K. Hwang, S. S. Chaurasia, Chad R. Jackson, G. Chan, D. Storm, P. Iuvone   +5 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Predicting contrast sensitivity functions with digital twins

Scientific Reports
We developed and validated digital twins (DTs) for contrast sensitivity function (CSF) across 12 prediction tasks using a data-driven, generative model approach based on a hierarchical Bayesian model (HBM).
Yukai Zhao, Luis Andres Lesmes, Michael Dorr, Zhong-Lin Lu   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Contrast visual acuity in patients with retinitis pigmentosa assessed by a contrast sensitivity tester

Indian Journal of Ophthalmology, 2012
Purpose: To assess contrast visual acuity (CVA) in patients with retinitis pigmentosa (RP) and compare the result with standard visual acuity (VA), retinal thickness, status of inner segment/outer segment junction, and central visual field. Materials and
Maho Oishi, Hajime Nakamura, Masanori Hangai, Akio Oishi, Atsushi Otani, Nagahisa Yoshimura   +5 more
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Contrast‐enhanced MRI for breast cancer screening

Journal of Magnetic Resonance Imaging, 2019
Multiple studies in the first decade of the 21st century have established contrast‐enhanced breast MRI as a screening modality for women with a hereditary or familial increased risk for the development of breast cancer.
R. Mann, C. Kuhl, L. Moy
semanticscholar   +1 more source

Contrast Sensitivity and Asthenopia Analysis in Workers

Acta Medica Bulgarica
In the digital age, complaints of eyestrain, or asthenopia, have become increasingly common. This condition is often associated with prolonged near-work activities, such as extended use of computers or digital devices, with reported prevalence rates ...
Amalia H., Adiwardhani A., Devita A., Pratiwi M., Witjaksana R., Dewi A., Yousif E.   +6 more
doaj   +1 more source