Results 101 to 110 of about 8,469,152 (382)

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Confidence Level and Sensitivity Limits in High Contrast Imaging

, 2007
In long adaptive optics corrected exposures, exoplanet detections are currently limited by speckle noise originating from the telescope and instrument optics, and it is expected that such noise will also limit future high-contrast imaging instruments for
Bruce Macintosh, Christian Marois, David Lafreniere, Dohlen K., Macintosh B., Macintosh B., Potter D., Rene Doyon, Roddier F.   +8 more
core   +1 more source

On the sensitivity of generic porous optical sensors [PDF]

, 2012
A porous material was considered as a platform for optical sensing. It was envisaged that the porous material was infiltrated by a fluid which contains an agent to be sensed.
Abdulhalim, Alù, Bremer, Choi, Cook, De Stefano, Devender, Homola, Lakhtakia, Lakhtakia, Lakhtakia, Lakhtakia, Lovat, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Menzel, Messier, Michel, Michel, Michel, Navarro-Cía, Pinet, Polo, Polo, PoloMahalik, Pursel, Saarinen, Scarano, Schiebener, Shin, Simovski, Ward, Weiglhofer, Weiglhofer   +38 more
core   +2 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Circadian Rhythm of Contrast Sensitivity Is Regulated by a Dopamine–Neuronal PAS-Domain Protein 2–Adenylyl Cyclase 1 Signaling Pathway in Retinal Ganglion Cells

Journal of Neuroscience, 2013
Spatial variation in light intensity, called spatial contrast, comprises much of the visual information perceived by mammals, and the relative ability to detect contrast is referred to as contrast sensitivity (Purves et al., 2012).
Christopher K. Hwang, S. S. Chaurasia, Chad R. Jackson, G. Chan, D. Storm, P. Iuvone   +5 more
semanticscholar   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Fearful faces have a sensory advantage in the competition for awareness [PDF]

, 2015
Only a subset of visual signals give rise to a conscious percept. Threat signals, such as fearful faces, are particularly salient to human vision.
Adams, W. J., Garner, M., Hedger, N.
core   +2 more sources

Basal forebrain activation controls contrast sensitivity in primary visual cortex

BMC Neuroscience, 2013
BackgroundThe basal forebrain (BF) regulates cortical activity by the action of cholinergic projections to the cortex. At the same time, it also sends substantial GABAergic projections to both cortex and thalamus, whose functional role has received far ...
A. Bhattacharyya, Julia Veit, R. Kretz, I. Bondar, G. Rainer   +4 more
semanticscholar   +1 more source

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

Age-related deterioration of rod vision in mice [PDF]

, 2010
Even in healthy individuals, aging leads to deterioration in visual acuity, contrast sensitivity, visual field, and dark adaptation. Little is known about the neural mechanisms that drive the age-related changes of the retina and, more specifically ...
Crouch, Rosalie K, Fan, Jie, Kefalov, Vladimir J, Kolesnikov, Alexander V   +3 more
core   +2 more sources