Results 101 to 110 of about 6,621,534 (346)
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini+10 more
wiley +1 more source
Subtle disturbances of vision after optic neuritis elicited by studying contrast sensitivity. [PDF]
R.L. Zimmern+2 more
openalex +1 more source
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka+10 more
wiley +1 more source
Evaluation of visual acuity and contrast sensitivity in early cataract
Background and Objective: Age-related cataract is one of the most important causes of blindness. Early detection of cataracts can help alleviate the problems caused by this disease.
Monireh Mahjoob, Farkhonde Shahri
doaj
An investigation into the variation of human contrast sensitivity with age and ocular pathology. [PDF]
K. Arundale
openalex +1 more source
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair+17 more
wiley +1 more source
The primate retina contains two types of ganglion cells, with high and low contrast sensitivity. [PDF]
E. Kaplan, Robert Shapley
openalex +1 more source
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser+11 more
wiley +1 more source
Spatial contrast sensitivity and the diagnosis of amblyopia. [PDF]
A. Volkers+3 more
openalex +1 more source