Results 121 to 130 of about 1,757,364 (306)

Contrast sensitivity benefit of adaptive optics correction of ocular aberrations.

, 2011
While correcting the aberrations of the eye produces large increases in retinal image contrast, the corresponding improvement factors in the contrast sensitivity function have been little explored and results are controversial.
S. Marcos, Marcos, Susana, Mathur, A., Mathur, Ankit, Atchison, David A., de Gracia, Pablo, A. Mathur, D. A. Atchison, Gracia, Pablo de, P. de Gracia   +9 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Perceptual deficits and inattention in schizophrenia

, 2008
A number of investigators have found perceptual deficits in schizophrenic subjects. It has also been indicated that those with schizophrenia suffer from reduced attention.
John R. Skoyles, Bernt C. Skottun
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Contrast sensitivity in central and paracentral retina in age-related maculopathy

, 1988
Contrast sensitivity functions were measured in age related maculopathy (ARM) patients and age matched controls, in the central retina and 2 degrees, 5 degrees and 10 degrees in the paracentral retina. There was an overall loss of sensitivity in the ARM
Lovie-Kitchin, Jan E., Brown, Brian
core  

Mechanistic modeling of vertebrate spatial contrast sensitivity and acuity at low luminance

, 2012
The validity of the Barten theoretical model for describing the vertebrate spatial contrast sensitivity function (CSF) and acuity at scotopic light levels has been examined.
Westminster, Wathes, C M, Jarvis, J R, Wathes, C.M., Jarvis, J.   +4 more
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Advanced design and experimental validation of MRI contrast agents for fluid pressure mapping using microbubbles

, 2009
This work is related to monitoring fluid pressure using Magnetic Resonance Imaging or MRI and includes numerical simulations and experimental MRI. The nature of this study is such that techniques other than MRI have been extensively used to assess the ...
Morris, RH, Morris, Robert H
core  

Central and peripheral contrast sensitivity in thyroid eye disease

Indian Journal of Ophthalmology
Purpose: Assessment of central and peripheral contrast sensitivity (CS) in thyroid eye disease (TED) with and without dysthyroid optic neuropathy (DON).
Kasturi Bhattacharjee, Obaidur Rehman, Parul Ichhpujani, Vatsalya Venkatraman   +3 more
doaj   +1 more source