Results 141 to 150 of about 3,443,078 (337)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Intersession Repeatability of Contrast Sensitivity Scores in Age-Related Macular Degeneration [PDF]

, 2009
Praveen J. Patel, Fred K. Chen, Gary S. Rubin, Adnan Tufail   +3 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Correlation of visual acuity and contrast sensitivity in visually disabled patients of moderate to severe diabetic retinopathy

, 2018
M. K. Singh, V. P. Singh, P. Bhushan, RP Maurya, Pradyumn Chaturvedi   +4 more
openalex   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Contrast Sensitivity Loss in Glaucoma Using the Reaction Time Paradigm [PDF]

Emmanuel U Ezeuchu
openalex   +1 more source

Determine Sensitivity of Diffusion Weighted Imaging for Diagnosis of Hepatocellular Carcinoma, Keeping the Liver Dynamic Post Contrast MRI as Gold Standard [PDF]

, 2022
Raana Kanwal
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Extending Treatment Duration in Perceptual Learning for Amblyopia

Ophthalmology Science
Purpose: Perceptual learning (PL) is a novel therapeutic approach for the treatment of amblyopia. This study evaluated whether extending the duration of PL could yield sustained therapeutic benefits in amblyopia management.
Yusong Zhou, MD, Qingqing Ye, MB, Xuan Qiu, MD, PhD, Zixuan Xu, MD, Yunsi He, MD, Ying Yao, MD, Yangfei Pang, MD, Wentong Yu, MD, Yudan Zhong, MM, Qiuying Li, MM, Lei Feng, MB, Junpeng Yuan, BS, Yun Wen, MD, PhD, Zhonghao Wang, MD, Jinrong Li, MD, PhD   +14 more
doaj   +1 more source

Quick contrast sensitivity assessment in primates using an exploratory search task

, 2019
Mariana M. B. Cardoso, Najib J. Majaj, Gerick M. Lee, Krysten Garcia, Lynne Kiorpes   +4 more
openalex   +1 more source