Results 141 to 150 of about 8,367,182 (364)

Psychophysical measurement of contrast sensitivity in the behaving mouse.

Journal of Neurophysiology, 2012
To understand how activity in mammalian neural circuits controls behavior, the mouse is a promising model system due to the convergence of genetic, optical, and physiological methods.
M. Histed, L. A. Carvalho, J. Maunsell
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Alterations in center-surround contrast suppression in patients with major depressive disorder

Scientific Reports
Previous pattern electroretinogram studies indicate reduced retinal contrast gain in patients with a major depressive disorder (MDD) which may contribute to alterations in visual perception.
Kathrin Nickel, Sven P. Heinrich, Malina Beringer, Dominique Endres, Kimon Runge, Sebastian Küchlin, Simon Maier, Michael Bach, Katharina Domschke, Ludger Tebartz van Elst, Evelyn B. N. Friedel   +10 more
doaj   +1 more source

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib.

Proceedings of the National Academy of Sciences of the United States of America, 2004
Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene are reportedly associated with sensitivity of lung cancers to gefitinib (Iressa), kinase inhibitor.
W. Pao, V. Miller, M. Zakowski, J. Doherty, K. Politi, I. Sarkaria, Bhuvanesh Singh, R. Heelan, V. Rusch, L. Fulton, E. Mardis, Doris Kupfer, R. Wilson, M. Kris, H. Varmus   +14 more
semanticscholar   +1 more source

Clinical significance of stratifying prostate cancer patients through specific circulating genes

Molecular Oncology, EarlyView.
We tested a specific panel of genes representative of luminal, neuroendocrine and stem‐like cells in the blood of prostate cancer patients, showing predictive value from diagnosis to late stages of disease. This approach allows monitoring of treatment responses and outcomes at specific time points in trajectories.
Seta Derderian, Edouard Jarry, Arynne Santos, Quentin Vesval, Lucie Hamel, Rafael Sanchez‐Salas, Alexis Rompré‐Brodeur, Wassim Kassouf, Raghu Rajan, Fadi Brimo, Marie Duclos, Armen Aprikian, Simone Chevalier   +12 more
wiley   +1 more source

New sensitivity analysis subordinated to a contrast [PDF]

arXiv, 2013
In a model of the form $Y=h(X_1,\ldots,X_d)$ where the goal is to estimate a parameter of the probability distribution of $Y$, we define new sensitivity indices which quantify the importance of each variable $X_i$ with respect to this parameter of interest. The aim of this paper is to define {\it goal oriented sensitivity indices} and we will show that
arxiv  

The contrast sensitivity of the colour mechanisms of the human eye [PDF]

, 1968
Daniel G. Green
openalex   +1 more source

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

Evaluation of visual acuity and contrast sensitivity in early cataract

مجله دانشگاه علوم پزشکی گرگان, 2021
Background and Objective: Age-related cataract is one of the most important causes of blindness. Early detection of cataracts can help alleviate the problems caused by this disease.
Monireh Mahjoob, Farkhonde Shahri
doaj  

Factors Affecting Contrast Sensitivity in Healthy Individuals: A Pilot Study

Türk Oftalmoloji Dergisi, 2017
Objectives: To determine the demographic and ocular features affecting contrast sensitivity levels in healthy individuals. Materials and Methods: Seventy-four eyes of 37 subjects (7-65 years old) with refractive errors less than 1.0 diopter, no history ...
Arzu Seyhan Karatepe, Süheyla Köse, Sait Eğrilmez   +2 more
doaj   +1 more source