Results 141 to 150 of about 8,469,152 (382)

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Effect of Fasting on Contrast Sensitivity in Healthy Males

open access: yesJournal of Ophthalmic & Vision Research, 2019
Purpose: To evaluate the effect of fasting on contrast sensitivity (CS) in healthy male individuals during the month of Ramadan. Methods: This study included 45 healthy male individuals, aged between 20 and 40 years, working in the same environment.
Zarife Ekici Gok   +2 more
doaj   +1 more source

Loss of primary cilia promotes EphA2‐mediated endothelial‐to‐mesenchymal transition in the ovarian tumor microenvironment

open access: yesMolecular Oncology, EarlyView.
Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho   +11 more
wiley   +1 more source

Contrast sensitivity measurements in acute and resolved optic neuritis. [PDF]

open access: bronze, 1984
Roy W. Beck   +3 more
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Analysis of dynamic system optimum and externalities with departure time choice [PDF]

open access: yes, 2006
This paper aims to analyse the dynamic system optimal assignment with departure time choice, which is an important, yet underdeveloped area. The main contribution of this paper is the necessary conditions and the sensitivity analysis for dynamic system
Chow, A.H.F.
core  

Spatial contrast sensitivity and the diagnosis of amblyopia. [PDF]

open access: bronze, 1987
A. Volkers   +3 more
openalex   +1 more source

Home - About - Disclaimer - Privacy