Results 101 to 110 of about 2,583,441 (289)

Understanding contrast perception in amblyopia: a psychophysical analysis of the ON and OFF visual pathways

Frontiers in Psychology
PurposeThe study aimed to explore potential discrepancies in contrast sensitivity in the ON and OFF visual pathways among individuals with amblyopia compared to controls.MethodsEleven adult amblyopes (26.2 ± 4.4 [SD] years old) and 10 controls (24.6 ± 0 ...
Junhan Wei, Junhan Wei, Junhan Wei, Ziyun Cheng, Ziyun Cheng, Deying Kong, Wenman Lin, Wenman Lin, Robert F. Hess, Jiawei Zhou, Jiawei Zhou, Alexandre Reynaud   +11 more
doaj   +1 more source

Publish or perish: The art of scientific writing

Indian Journal of Ophthalmology, 2014
Publishing manuscripts is the only way by which scientists communicate with each other. In recent times, there is an increasing desire to publish manuscripts from the developing world for a variety of reasons.
Sabyasachi Sengupta, Dhananjay Shukla, Pradeep Ramulu, Sundaram Natarajan, Jyotirmay Biswas   +4 more
doaj   +1 more source

The potential of discs from a "mean Green function"

, 2012
By using various properties of the complete elliptic integrals, we have derived an alternative expression for the gravitational potential of axially symmetric bodies, which is free of singular kernel in contrast with the classical form.
A. Trova, Ambastha, Ansorg, Arnaboldi, Bannikova, Baruteau, Binney, Bodo, Clement, Cohl, Collin-Souffrin, Cox, Curry, Cvijovic, Cvijović, Dubrulle, Durand, F. Hersant, Fromang, Fukushima, Gradshteyn, Hachisu, Hennebelle, Huré, Huré, Huré, Huré, Huré, Huré, Huré, Huré, J.M. Huré, Kellogg, Lass, Mestel, Müller, Pierens, Pringle, Prudnikov, Schulz, Schulz, Shakura, Stone, Tresaco, Vogt, Vogt, Šubr   +46 more
core   +3 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Implications of LHC Searches on SUSY Particle Spectra: The pMSSM Parameter Space with Neutralino Dark Matter

, 2011
We study the implications of LHC searches on SUSY particle spectra using flat scans of the 19-parameter pMSSM phase space. We apply constraints from flavour physics, g_mu-2, dark matter and earlier LEP and Tevatron searches.
A. Arbey, A. Arbey, A. Arbey, A. Arbey, A. Arbey, A. Djouadi, A. Djouadi, A. Djouadi, A.G. Akeroyd, A.G. Akeroyd, A.J. Buras, A.L. Read, B. Allanach, B.C. Allanach, B.C. Allanach, B.C. Allanach, B.C. Allanach, B.C. Allanach, C. Bobeth, C. Bobeth, C. Bobeth, C.F. Berger, D. Eriksson, E. Komatsu, F. Mahmoudi, F. Mahmoudi, F. Mahmoudi, F. Mahmoudi, G. Bayatian, G. Belanger, H. Lai, J.A. Conley, J.R. Ellis, J.R. Ellis, J.R. Ellis, J.R. Ellis, K. Babu, K. Hagiwara, K. Nakamura, M. Battaglia, M. Cacciari, M. Cacciari, M. Davier, M. Farina, M. Hindmarsh, M. Misiak, M. Misiak, M. Muhlleitner, M. Perelstein, M.S. Carena, O. Buchmueller, O. Buchmueller, P. Bechtle, P. Bechtle, P.Z. Skands, R. Barbieri, R. Boughezal, R. Brun, R. Trotta, S. Choudhury, S. Heinemeyer, S. Heinemeyer, S. Heinemeyer, S.P. Martin, S.S. AbdusSalam, T. Goecke, T. Goecke, T. Sjostrand, Z. Ahmed   +68 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Lighting conditions and optical filters effects on visual performance of speleologists exposed to cave environments

International Journal of Speleology, 2016
The aim of this study is to evaluate lighting conditions and speleologists’ visual performance using optical filters when exposed to the lighting conditions of cave environments. A cross-sectional study was conducted.
Carla Costa Lança, Nádia Fernandes, Ana Monteiro, Ana Almeida   +3 more
doaj   +1 more source