Results 91 to 100 of about 918,979 (303)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Event-driven control with deadline optimization for linear systems with stochastic delays [PDF]

, 2018
This work presents a novel control strategy for systems with actuation delays with known stochastic distribution, which improves upon previously proposed deadline-driven and event-driven strategies.
van Horssen, E.P., Prakash, S, Heemels, W.P.M.H., Prakash, S., Horssen, EP Eelco van, Heemels, WPMH Maurice, Guerreiro Tomé Antunes, D.J., Guerreiro Tomé Antunes, DJ Duarte   +7 more
core   +2 more sources

Multi-Step Prediction of Airborne Load Separation Trajectory and Attitude Based on RCF-Transformer

Aerospace
Accurate and efficient data-driven prediction of embedded airborne load separation trajectories and attitudes can not only significantly improve the safety of the separation process but also substantially reduce reliance on costly aerodynamic simulations
Xin Zheng, Xutong Zhang, Xue Zhang, Jingjie Li   +3 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Launcher attitude control: some additional design and optimization tools [PDF]

, 2003
This paper deals with the launcher attitude control during atmospheric flight. A two step approach combining an H1 control design and an optimization procedure is proposed.
Clément, Benoît, Alazard, Daniel, Imbert, Nicole, Apkarian, Pierre   +3 more
core  

Amidst centralized and distributed frequency control in power systems

, 2016
We propose a novel frequency control approach in between centralized and distributed architectures, that is a generalized continuous-time feedback control version of the dual decomposition optimization method.
GRAMMATICO, SERGIO, Florian Dorfler, Sergio Grammatico, Dörfler, F., Grammatico, S, Dörfler, Florian, Dörfler, F, Grammatico, S.   +7 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Design of Fluxgate Current Sensor Based on Magnetization Residence Times and Neural Networks

Sensors
This study introduces a novel fluxgate current sensor with a compact, ring-shaped configuration that exhibits improved performance through the integration of magnetization residence times and neural networks. The sensor distinguishes itself with a unique
Jingjie Li, Wei Ren, Yanshou Luo, Xutong Zhang, Xinpeng Liu, Xue Zhang   +5 more
doaj   +1 more source