Results 111 to 120 of about 1,613,291 (363)

Online-Computation Approach to Optimal Control of Noise-Affected Nonlinear Systems with Continuous State and Control Spaces [PDF]

, 2007
22.10.13 KB. Ok to add author version to spiral.A novel online-computation approach to optimal control of nonlinear, noise-affected systems with continuous state and control spaces is presented.
Deisenroth, Marc P, Weissel, Florian, Ohtsuka, Toshiyuki, Hanebeck, Uwe D   +3 more
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Model simplification and optimization of a passive wind turbine generator [PDF]

, 2009
In this paper, the design of a "low cost full passive structure" of wind turbine system without active electronic part (power and control) is investigated. The efficiency of such device can be obtained only if the design parameters are mutually adapted
B. Sareni, Sareni, Bruno, Abdelli, Abdenour, Roboam, Xavier, A. Abdelli, D.H. Tran, Tran, Duc-Hoan, X. Roboam, Tran, Duc Hoan   +8 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Optimization Methods Applied to Aerodynamic Flow Control [PDF]

, 2012
International audienceThis study deals with the use of optimization algorithms to determine efficient param- eters of flow control devices. To improve the performance of systems characterized by detached flows and vortex shedding, the use of flow control
Labroquère, Jérémie, Duvigneau, Régis   +1 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Robust Model Predictive Control for Process Control and Supply Chain Optimization [PDF]

, 2009
Model Predictive Control (MPC) is traditionally designed assuming no model mismatch and tuned to provide acceptable behavior when mismatch occurs. This thesis extends the MPC design to account for explicit mismatch in the control and optimization of a ...
Li, Xiang
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Multi-Step Prediction of Airborne Load Separation Trajectory and Attitude Based on RCF-Transformer

Aerospace
Accurate and efficient data-driven prediction of embedded airborne load separation trajectories and attitudes can not only significantly improve the safety of the separation process but also substantially reduce reliance on costly aerodynamic simulations
Xin Zheng, Xutong Zhang, Xue Zhang, Jingjie Li   +3 more
doaj   +1 more source