Results 101 to 110 of about 918,979 (303)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Variance-constrained filtering for nonlinear systems with randomly occurring quantized measurements: recursive scheme and boundedness analysis

Advances in Difference Equations, 2019
In this paper, the robust optimal filtering problem is discussed for time-varying networked systems with randomly occurring quantized measurements via the variance-constrained method. The stochastic nonlinearity is considered by statistical form.
Chaoqing Jia, Jun Hu
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Monotone iterative method for two-point fractional boundary value problems

Advances in Difference Equations, 2018
In this work, we deal with two-point Riemann–Liouville fractional boundary value problems. Firstly, we establish a new comparison principle. Then, we show the existence of extremal solutions for the two-point Riemann–Liouville fractional boundary value ...
Bo Tang, Jing Zhao, Zhenhai Liu
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Developments in model-based optimization and control: distributed control and industrial applications

, 2015
This book deals with optimization methods as tools for decision making and control in the presence of model uncertainty. It is oriented to the use of these tools in engineering, specifically in automatic control design with all its components: analysis ...
Pereira, Fernando, Olaru, Sorin, Grancharova, Alexandra, Lobo Pereira, Fernando   +3 more
core   +1 more source

Lateral fligh control design for a highly flexible aircraft using a nonsmooth method [PDF]

, 2009
This paper describes a nonsmooth optimization technique for designing a lateral flight control law for a highly flexible aircraft. Flexible modes and high-dimensional models pose a major challenge to modern control design tools.
H. D. Tuan, Tuan, Hoang, A. M. Simoes, Simoes, Alberto, Alazard, Daniel, D. Alazard, P. Apkarian, Apkarian, Pierre   +7 more
core   +1 more source

Selected Reports of the Group on Simulation, Optimization and Control, 1973-1983

, 2023
The Group on Simulation, Optimization and Control (G-SOC) operated from 1973 to 1983. Co-ordinated by John W. Bandler, its members came from the Departments of Electrical Engineering and Chemical Engineering. Faculty members of G-SOC included Dr.
Bandler, John
core   +1 more source

Opportunities and Challenges of Artificial Intelligence for Green Manufacturing in the Process Industry

Engineering, 2019
Smart manufacturing is critical in improving the quality of the process industry. In smart manufacturing, there is a trend to incorporate different kinds of new-generation information technologies into process-safety analysis.
Shuai Mao, Bing Wang, Yang Tang, Feng Qian   +3 more
doaj   +1 more source