Results 121 to 130 of about 1,613,291 (363)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Selected Reports of the Group on Simulation, Optimization and Control, 1973-1983
, 2023 The Group on Simulation, Optimization and Control (G-SOC) operated from 1973 to 1983. Co-ordinated by John W. Bandler, its members came from the Departments of Electrical Engineering and Chemical Engineering. Faculty members of G-SOC included Dr.
Bandler, John
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Advances in Difference Equations, 2019 In this paper, the robust optimal filtering problem is discussed for time-varying networked systems with randomly occurring quantized measurements via the variance-constrained method. The stochastic nonlinearity is considered by statistical form.
Chaoqing Jia, Jun Hu
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Combining stochastic programming and optimal control to solve multistage stochastic optimization problems [PDF]
In this contribution we propose an approach to solve a multistage stochastic programming problem which allows us to obtain a time and nodal decomposition of the original problem.
Elio Canestrelli, Diana Barro
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Monotone iterative method for two-point fractional boundary value problems
Advances in Difference Equations, 2018 In this work, we deal with two-point Riemann–Liouville fractional boundary value problems. Firstly, we establish a new comparison principle. Then, we show the existence of extremal solutions for the two-point Riemann–Liouville fractional boundary value ...
Bo Tang, Jing Zhao, Zhenhai Liu
doaj +1 more source
Selection/control concurrent optimization of BLDC motors for industrial robots. [PDF]
PLoS One, 2023 Padilla-García EA +3 more
europepmc +1 more source