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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Achieving stable and versatile bipedal locomotion remains a major challenge in robotics, with applications in personal assistance, healthcare, and search and rescue. The hybrid zero dynamics (HZD) framework, based on virtual constraints, has shown strong
William Suliman +2 more
doaj +1 more source
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
This study aims to establish a monocular camera-based system that uses a generative adversarial network (GAN) to estimate a 3D pose of a human and his/her orientation relative to the camera from images by considering anatomical knowledge such as segment ...
Akisue KURAMOTO +2 more
doaj +1 more source
A Product Line Systems Engineering Process for Variability Identification and Reduction
Software Product Line Engineering has attracted attention in the last two decades due to its promising capabilities to reduce costs and time to market through reuse of requirements and components.
Dickerson, Charles +4 more
core +1 more source
Recent advances on filtering and control for nonlinear stochastic complex systems with incomplete information: A survey [PDF]
This Article is provided by the Brunel Open Access Publishing Fund - Copyright @ 2012 Hindawi PublishingSome recent advances on the filtering and control problems for nonlinear stochastic complex systems with incomplete information are surveyed.
Liang, J, Liu, Y, Shen, B, Wang, Z
core +3 more sources
Molecular bases of circadian magnesium rhythms across eukaryotes
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
This paper aims to find the best variant of Cuckoo Search Algorithm that makes the step size of Lévy flight adaptive. For this reason, we introduce a new variant of CSA called Damped Cuckoo Search (DCS) in which the step size of Lévy ...
Mohamed Reda +3 more
doaj +1 more source
Fighter aircraft flight control technology design requirements [PDF]
The evolution of fighter aircraft flight control technology is briefly surveyed. Systems engineering, battle damage considerations for adaptive flutter suppression, in-flight simulation, and artificial intelligence are briefly ...
Nelson, W. E., Jr.
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source

