Results 41 to 50 of about 233,556 (243)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Accurate surgery time prediction (ASTP) strategy based on artificial intelligence techniques

Scientific Reports
Accurate timing prediction of surgery is essential for efficient operating room scheduling and ensuring patient care. This study proposes a two-layered Accurate Surgical Time Prediction (ASTP) framework.
Rana Mohamed El-Balka, Asmaa H. Rabie, Ahmed I. Saleh, Noha Sakr   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Design of Integral Sliding Mode Controller for Servo DC Motor

مجلة النهرين للعلوم الهندسية, 2017
DC servo motor is simple in construction and control and has many applications. However, the uncertainties due to its parameters changes such as load torque and friction are an evitable.
Bashar Fateh Midhat, Amjad Jaleel Humaidi, Firas A. Raheem   +2 more
doaj  

Dimension-wise adaptive snake optimizer with Sobol initialization and Lévy spiral search for solar photovoltaic cell model optimization

Scientific Reports
Metaheuristic algorithms have received significant attention given their ability to handle complex, nonlinear, and high-dimensional optimization problems.
Manar H. Elgammal, Eman M. El-Gendy, Labib M. Labib, Amira Y. Haikal   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Hand-like autonomous flying robot for airborne grasping and interaction

Nature Communications
Birds’ extraordinary aerial agility and environmental interaction enable complex tasks such as mid-air hunting, perching, and nest-building, inspiring the development of advanced aerial robots with similar manipulation capabilities.
Yuze Wu, Fan Yang, Rui Jin, Yuhang Zhong, Junjie Wang, Xuankang Wu, Fei Gao   +6 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Internal and external disturbances aware motion planning and control for quadrotors

IET Cyber-systems and Robotics
Resilient motion planning and control, without prior knowledge of disturbances, are crucial to ensure the safe and robust flight of quadrotors. The development of a motion planning and control architecture for quadrotors, considering both internal and ...
Xiaobin Zhou, Miao Wang, Can Cui, Yongchao Wang, Chao Xu, Fei Gao   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source