Results 81 to 90 of about 2,353,723 (293)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Perturbative Determination of Mass Dependent $O(a)$ Improvement Coefficients for the Vector and Axial Vector Currents with a Relativistic Heavy Quark Action

, 2004
We carry out a perturbative determination of mass dependent renormalization factors and $O(a)$ improvement coefficients for the vector and axial vector currents with a relativistic heavy quark action, which we have designed to control $m_Qa$ errors by ...
Ali Khan, Ali Khan, Aoki, Aoki, Aoki, Aoki, Aoki, Aoki, Aoki, de Forcrand, El-Khadra, Kuramashi, Sinya Aoki, Takaishi, Taniguchi, Yasuhisa Kayaba, Yoshinobu Kuramashi   +16 more
core   +1 more source

Solvability of an optimal control problem in coefficients for ill-posed elliptic boundary-value problems

Electronic Journal of Differential Equations, 2014
We study an optimal control problem (OCP) associated to a linear elliptic equation $-\hbox{div}(A(x)\nabla y+C(x)\nabla y)=f$. The characteristic feature of this control object is the fact that the matrix $C(x)$ is skew-symmetric and belongs to $
Ciro D'Apice, Umberto De Maio, Peter I. Kogut, Rosanna Manzo   +3 more
doaj  

On an Optimal -Control Problem in Coefficients for Linear Elliptic Variational Inequality

Abstract and Applied Analysis, 2013
We consider optimal control problems for linear degenerate elliptic variational inequalities with homogeneous Dirichlet boundary conditions. We take the matrix-valued coefficients in the main part of the elliptic operator as controls in .
Olha P. Kupenko, Rosanna Manzo
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Understanding deterministic diffusion by correlated random walks

, 2002
Low-dimensional periodic arrays of scatterers with a moving point particle are ideal models for studying deterministic diffusion. For such systems the diffusion coefficient is typically an irregular function under variation of a control parameter.
Bunimovich L A, Dana I, Dorfman J R, Dorfman J R, Fujisaka H, Gaspard P, Gaspard P, Harayama T, Harayama T, Klages R, Klages R, Klages R, Korabel N, Lasota A, Leboeuf P, Mandelbrot B, Moran B, N Korabel, R Klages   +18 more
core   +1 more source

Adaptive event-triggered output-feedback stabilization for nonlinear systems with function control coefficients

Nonlinear Analysis
This article presents an adaptive event-triggered control scheme for global stabilization of uncertain nonlinear systems with function control coefficients, input matching uncertainty, and unknown polynomial-function rates.
Yu Zhang, Shaoli Jin, Hui Li, Yue Pan
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Absolute stability of large-scale time-delay Lurie indirect control systems with unbounded coefficients

Advances in Difference Equations, 2017
We study the absolute stability of large-scale time-delay Lurie indirect control systems with unbounded coefficients. Based on Lyapunov-Krasovskii functional approach, we derive some novel absolute stability conditions for this class of Lurie systems ...
Xiao Yu, Fucheng Liao
doaj   +1 more source