Results 171 to 180 of about 32,647 (264)

Leisure‐Time Physical Activity on Age‐Modelled Trajectories of Body Mass Index and Obesity Risk Throughout Life: Multivariable Regression and Mendelian Randomization Analyses Using Electronic Health Record Data From the CORDELIA‐Catalunya Study

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To assess whether self‐reported leisure‐time physical activity, moderate‐to‐vigorous leisure‐time physical activity, and genetically determined cardiorespiratory fitness are associated with age‐related BMI trajectories and incident obesity. Methods We pooled 14 993 adults (30–90 years; 52.7% women; cohorts: REGICOR‐ACRISC, ILERVAS, ARTPER)
Javier Hernando‐Redondo, Anna Camps‐Vilaró, Roberto Elosua, Eleonora Fornara, Marcelino Bermúdez‐López, Pere Torán‐Monserrat, Ainara Jiménez‐Navarro, José M. Valdivielso, Víctor M. López‐Lifante, Tomàs Salas‐Fernández, Serafí Cambray, Raquel Cruz, Jaume Marrugat, Álvaro Hernáez   +13 more
wiley   +1 more source

The Overexpression of Myelin and Lymphocyte Protein (MAL) Downregulates MUC1 and Enhances Cisplatin Sensitivity in Non-Small Cell Lung Cancer Cells. [PDF]

J Cancer
Saldaña-Villa AK, Vázquez-Almazán B, Flores-Maldonado C, Vizuet-de-Rueda JC, Oropeza-Durán EN, Bonilla-Delgado J, Cortés-Malagón EM, Contreras RG, Teran LM, Ortiz-Quintero B, Lara-Lemus R.   +10 more
europepmc   +1 more source

Real‐World Effectiveness and Safety of Finerenone in People With Type 2 Diabetes and Chronic Kidney Disease: A Spanish Multicentre Retrospective Observational Study (MEDFINE‐RWD)

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real‐world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes ...
Oscar Moreno‐Pérez, Antonio Tejera‐Muñoz, Patricia Tomás‐Gómez, Federico Vázquez‐San Miguel, Virginia Soria‐Utrilla, Ada María Roldán‐Sánchez, Maya Sánchez‐Baya, Jersy Cárdenas‐Salas, Blanca Timón‐Vázquez, Juan J. Gorgojo‐Martínez, Ines Modrego‐Pardo, Irea Fernández‐Xove, Jose Carlos Fernández‐García, Rebeca Reyes‐García   +13 more
wiley   +1 more source

Measles at the U.S.-Mexico border: The fragility of cross-border disease control. [PDF]

PLOS Glob Public Health
Chacon-Cruz E, Wells K, Real-Ramírez J, Torres T, Saltigeral-Simental LP, Felberg J, Lopatynsky-Reyes EZ.   +6 more
europepmc   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Hotspot-based integrated serosurveillance of neglected tropical diseases, malaria, and vaccine-preventable diseases in urban Guyana. [PDF]

Rev Panam Salud Publica
Niles-Robin RA, Sampson A, Valz O, Scott O, Dickson KE, Escalada R, Nicholson D, Woolford J, Ade MP, Carvalho Scholte R, Luciañez A, Bravo P, Rey-Benito G, Ibarra-Ozcariz S, Morice A, Saboyá-Díaz MI.   +15 more
europepmc   +1 more source

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Outpatient Parenteral Antimicrobial Therapy for <i>Pseudomonas aeruginosa</i> Infections: Effectiveness and Safety. [PDF]

Pharmaceutics
Suárez-Casillas P, Mejías-Trueba M, Martínez Alemany I, Navarro Amuedo L, Praena Segovia J, de Alarcón González A, Luque Márquez R, Palacios-Baena ZR, Carmona-Caballero JM, Sánchez Oliva JM, Gil-Navarro MV, García Gutiérrez M, Herrera-Hidalgo L, Poyato Borrego M, López-Cortés LE, Cisneros JM.   +15 more
europepmc   +1 more source

Uso de probióticos para el control de enfermedades orales.

Revista de la Asociación Dental Mexicana
Sthefany Córdova, Paola Patricia Orellana Bravo, Carlos Andrade, Patricio Sarmiento Criollo   +3 more
openaire   +1 more source

History of sexually transmitted infections among mpox cases in the 2022 outbreak in Spain

HIV Medicine, EarlyView.
Abstract Objective The aim was to describe the history of sexually transmitted infections (STIs) among adult mpox men cases and to analyse sociodemographic and epidemiological characteristics according to the presence or absence of any STI diagnosed 1 or 6 months previous to mpox diagnosis during the 2022 outbreak in Spain.
Aina March‐Yagüe, Diana Toledo, Asunción Díaz, Pere Godoy, Olaia Pérez‐Martínez, Carles Pericas, Alonso Sanchez‐Migallon, María Dolores Chirlaque, Jesús Ospina, María Grau, Francisco Roig, Angela Domínguez, and the MONKPOX‐ESP22 Subproject 3.2 Working Group, Nicola Lorusso, Miguel Mingo, Eduardo Briones, Laura García, Julio Morais, Óscar Pérez, Álvaro Torres, Virginia Álvarez, Saray Martín, María del Carmen Pacheco, Nuria Soldevila, Itziar Martínez, Jacobo Mendioroz, Ana Martínez, Joan Pau Millet, Lesly Acosta, Ana Vázquez, Carla Guerra‐Tort, Lucía Martin‐Gisbert, Lorena Aroca, Lorena Pérez, Bernardo Guzmán, María Jose Sierra   +35 more
wiley   +1 more source