Results 101 to 110 of about 3,374,155 (295)

MSCADMpox: A novel multi-stage classification model for effective monkeypox classification

Complex & Intelligent Systems
Monkeypox (Mpox) is a skin disease that appeared after the COVID-19 pandemic and spread to 127 countries. Early diagnosis of Mpox according to symptoms is difficult because it is closer to measles and chickenpox symptoms, while both lesions are ...
Doaa Ahmed Arafa, Sarah M. Ayyad, Mohamed M. Abdelsalam   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A new framework for mental illnesses diagnosis using wearable devices aided by improved convolutional neural network

Scientific Reports
Stress inherent in the modern world is considered one of the main causes of Mental Health Disorders (MHDs) that spread in every country around the world.
Hend S. Saad, John F. W. Zaki, Mohamed M. Abdelsalam   +2 more
doaj   +1 more source

Advanced technologies for Mission Control Centers [PDF]

Advance technologies for Mission Control Centers are presented in the form of the viewgraphs. The following subject areas are covered: technology needs; current technology efforts at GSFC (human-machine interface development, object oriented software ...
Dalton, John T., Hughes, Peter M.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Human Factors Considerations in System Design [PDF]

Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined.
Mitchell, C. M., Moe, K. L., Vanbalen, P. M.   +2 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Design and Simulation of L1-Adaptive Controller for Position Control of DC Servomotor

Al-Khawarizmi Engineering Journal, 2017
This paper presents L1-adaptive controller for controlling uncertain parameters and time-varying unknown parameters to control the position of a DC servomotor.
Mohammed Ali S. Mohammed, Amjad J. Humaidi, Ammar A. Al jodah   +2 more
doaj  

Temperature and Flow Decoupling Control for Air Heater Systems [PDF]

Journal of Electrical and Electronics Engineering, 2014
In this paper it is presented an optimized practical solution for controlling the temperature and flow of a multivariable process. The solution is based on software architecture that solves the technical problem of coupling between the two parameters ...
SOPONARIU Alexandru, LUPU Ciprian
doaj  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source