Results 121 to 130 of about 7,679,447 (385)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

NONLINEAR INTEGRAL CONTROL DESIGN FOR DC MOTOR SPEED CONTROL WITH UNKNOWN AND VARIABLE EXTERNAL TORQUE

Journal of Engineering and Sustainable Development, 2016
In this work, a nonlinear integral controller is proposed for a Direct Current (DC) motor model in the presence of a variable and unknown external load and for a constant and variable reference velocity. The nonlinear integral term is designed simply by
Shibly Ahmed Al-Samarraie, Bashar Fateh Midhat, Ivan Isho Gorial   +2 more
doaj  

Resident research associateships. Postdoctoral and senior research awards: Opportunities for research at the Jet Propulsion Laboratory [PDF]

Opportunities for research as part of NASA-sponsored programs at the JPL cover: Earth and space sciences; systems; telecommunications science and engineering; control and energy conversion; applied mechanics; information systems; and observational ...

core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Back stepping-Based-PID-Controller Designed for an Artificial Pancreas model

Al-Khawarizmi Engineering Journal, 2011
Artificial pancreas is simulated to handle Type I diabetic patients under intensive care by automatically controlling the insulin infusion rate. A Backstepping technique is used to apply the effect of PID controller to blood glucose level since there is ...
Taghreed M. Mohammad Ridha, Mina Qais Kadhum, Shaima Mahmou Mahdi   +2 more
doaj  

A new framework for mental illnesses diagnosis using wearable devices aided by improved convolutional neural network

Scientific Reports
Stress inherent in the modern world is considered one of the main causes of Mental Health Disorders (MHDs) that spread in every country around the world.
Hend S. Saad, John F. W. Zaki, Mohamed M. Abdelsalam   +2 more
doaj   +1 more source

Optogenetics for light control of biological systems

Nature Reviews Methods Primers, 2022
V. Emiliani, E. Entcheva, R. Hedrich, P. Hegemann, K. Konrad, C. Lüscher, M. Mahn, Z. Pan, Ruth R. Sims, J. Vierock, O. Yizhar   +10 more
semanticscholar   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

MSCADMpox: A novel multi-stage classification model for effective monkeypox classification

Complex & Intelligent Systems
Monkeypox (Mpox) is a skin disease that appeared after the COVID-19 pandemic and spread to 127 countries. Early diagnosis of Mpox according to symptoms is difficult because it is closer to measles and chickenpox symptoms, while both lesions are ...
Doaa Ahmed Arafa, Sarah M. Ayyad, Mohamed M. Abdelsalam   +2 more
doaj   +1 more source