Results 81 to 90 of about 7,679,447 (385)

Disturbance Observer-based Robust Control and Its Applications: 35th Anniversary Overview

open access: yes, 2019
Disturbance Observer has been one of the most widely used robust control tools since it was proposed in 1983. This paper introduces the origins of Disturbance Observer and presents a survey of the major results on Disturbance Observer-based robust ...
Oboe, Roberto   +2 more
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

open access: yesFEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican   +7 more
wiley   +1 more source

Design of Integral Sliding Mode Controller for Servo DC Motor

open access: yesمجلة النهرين للعلوم الهندسية, 2017
DC servo motor is simple in construction and control and has many applications. However, the uncertainties due to its parameters changes such as load torque and friction are an evitable.
Bashar Fateh Midhat   +2 more
doaj  

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

An Innovative Damped Cuckoo Search Algorithm With a Comparative Study Against Other Adaptive Variants

open access: yesIEEE Access, 2019
This paper aims to find the best variant of Cuckoo Search Algorithm that makes the step size of Lévy flight adaptive. For this reason, we introduce a new variant of CSA called Damped Cuckoo Search (DCS) in which the step size of Lévy ...
Mohamed Reda   +3 more
doaj   +1 more source

V-Model Role Engineering [PDF]

open access: yes
The paper focuses on role engineering which is an important topic in the development of access control system, particularly when considering Role Based Access Control – RBAC models.
Radu CONSTANTINESCU
core  

Control of Excitation Energy Transfer in Condensed Phase Molecular Systems by Floquet Engineering

open access: yes, 2018
Excitation energy transfer (EET) is one of the most important processes in both natural and artificial chemical systems including, for example, photosynthetic complexes and organic solar cells.
Ishizaki, Akihito, Phuc, Nguyen Thanh
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

open access: yesFEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura   +8 more
wiley   +1 more source

Plant Process Emulator [PDF]

open access: yes, 2017
The purpose of this project is to provide the VCU Engineering Students with a training system to simulate the use of Industrial Automation systems. Students need a wide variety of training systems to adequately train and improve their knowledge of all ...
Adu-Mensah, David   +3 more
core   +1 more source

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