Results 51 to 60 of about 9,499 (219)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Solvability of an optimal control problem in coefficients for ill-posed elliptic boundary-value problems

Electronic Journal of Differential Equations, 2014
We study an optimal control problem (OCP) associated to a linear elliptic equation $-\hbox{div}(A(x)\nabla y+C(x)\nabla y)=f$. The characteristic feature of this control object is the fact that the matrix $C(x)$ is skew-symmetric and belongs to $
Ciro D'Apice, Umberto De Maio, Peter I. Kogut, Rosanna Manzo   +3 more
doaj  

Control of the Wave Equation by Time-Dependent Coefficient [PDF]

ESAIM: Control, Optimisation and Calculus of Variations, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chambolle, Antonin, Santosa, Fadil
openaire   +2 more sources

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Determination of control coefficients in intact metabolic systems [PDF]

Biochemical Journal, 1994
The control structure of a metabolic system can in principle be determined without the need for purification of the component enzymes and study of their kinetic properties, provided that their activities can be perturbed by amounts sufficient to produce measurable changes in the steady-state variables, i.e.
A, Cornish-Bowden, J H, Hofmeyr
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Control of a Segway with unknown control coefficient and input constraint

The International Journal of Fuzzy Logic and Intelligent Systems, 2016
This paper proposes a control method of the Segway with unknown control coefficient and input saturation. To design a simple controller for the Segway with the model uncertainty, the prescribed performance function is used. Furthermore, an auxiliary variable is introduced to deal with unknown time-varying control coefficient and input saturation ...
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Virtual Cell and Metabolic Control Analysis: Control Coefficients for Glycolytic Flux Are Highly Dependent on the Subsystem Selected for Analysis

Life
The metabolic control analysis (MCA) was applied to several subsystems selected from the model of human erythrocyte energy metabolism. These subsystems represent varying degrees of simplification of energy metabolism, from the simplest subsystem of the ...
Michael V. Martinov, Fazoil I. Ataullakhanov, Eugene S. Protasov, Victor M. Vitvitsky   +3 more
doaj   +1 more source

Fuzzy predictive control strategy of permanent magnet linear synchronous motor

Journal of Hebei University of Science and Technology, 2020
In order to solve the problem that the actual current cannot closely follow the given current or the predicted output voltage fluctuates too much due to the unreasonable selection of the weight coefficient when the model predictive control seeks the ...
Zheng LI, Wei FENG, Jiang ZHAO
doaj   +1 more source