Results 61 to 70 of about 9,499 (219)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

A new error analysis for finite element methods for elliptic Neumann boundary control problems with pointwise control constraints

Results in Applied Mathematics
We present a new error analysis for finite element methods for a linear-quadratic elliptic optimal control problem with Neumann boundary control and pointwise control constraints. It can be applied to standard finite element methods when the coefficients
Susanne C. Brenner, Li-Yeng Sung
doaj   +1 more source

Real time DSP-based adaptive controller implementation for 6/4 pole switched reluctance motor drive [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2005
This paper presents the design and implementation of an adaptive PID control system for a high performance Switched Reluctance Motor (SRM) drive. The concept behind the proposed control system is to use an adaptive PID controller in steady state as well ...
R. Arumugam, S. Paramasivam
doaj  

Substrate‐Controlled Response Coefficients in Thin Films

Advanced Science
Abstract To obtain materials with desired properties, material compositions are primarily altered, whereas thin films offer additional unique avenues. By combining state‐of‐the‐art first‐principles calculations and experimental investigations of thin films of strontium titanate as an exemplary representative of a broad class of ...
Marina Tyunina, Leonid L. Rusevich, Maxim Savinov, Tomas Kocourek, Oliva Pacherova, Alexandr Dejneka, Eugene A. Kotomin   +6 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A new optimization method for steam-liquid level intelligent control model in oil sands steam-assisted gravity drainage (SAGD) process

Petroleum Exploration and Development, 2016
In order to prevent steam breakthrough and improve thermal efficiency in the process of SAGD development of oil sands by real-time adjustment on injection-production temperature difference (Subcool) according to the growth situations of steam chamber ...
Guangyue LIANG, Shangqi LIU, Pingping SHEN, Yang LIU, Yanyan LUO   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Flow Control over the Blunt Trailing Edge of Wind Turbine Airfoils Using Circulation Control

Energies, 2018
A new partial circulation control (PCC) method is implemented on the blunt trailing edge DU97-Flatback airfoil, and compared with the traditional full circulation control (FCC) based on numerical analysis.
He-Yong Xu, Qing-Li Dong, Chen-Liang Qiao, Zheng-Yin Ye   +3 more
doaj   +1 more source

Characteristics and Controlling Factors of the Drought Runoff Coefficient [PDF]

Water, 2019
Increasing water demand due to population growth, economic development, and changes in rainfall patterns due to climate change are likely to alter the duration and magnitude of droughts. Understanding the relationship between low-flow conditions and controlling factors relative to the magnitude of a drought is important for establishing sustainable ...
openaire   +3 more sources