Results 71 to 80 of about 9,499 (219)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

PERFORMANCE CRITERION OF A TRANSIENT PROCESS AND ACCURACY FIGURES OF A ROCKET STABILIZATION SYSTEM

Авіаційно-космічна техніка та технологія, 2017
Equations given connection between criteria coefficients, control law, coordinates vectors of errors and the work of an inertial actuating link during transient process of a constant disturbing acceleration compensation for the case of a plain rotation ...
Вольт Васильевич Авдеев
doaj   +1 more source

Algorithms for the derivation of Flux and Concentration Control Coefficients [PDF]

Biochemical Journal, 1991
A computer program is described that derives the Flux and Concentration Control Coefficients for linear and branched metabolic pathways. The program prompts the user to enter a concise description of the metabolic pathway. From this description, the program constructs the appropriate equations in matrix form.
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Experimental investigation of spillover effect in system of active vibration control [PDF]

FME Transactions, 2014
Piezoelectric actuators are widely used in structural systems for active vibration control with the aim to enhance the performance of systems. The developed system of active vibration control consists of active structure, controller and high voltage ...
Jovanović Miroslav M., Simonović Aleksandar M., Zorić Nemanja D., Lukić Nebojša S., Stupar Slobodan N., Petrović Ana S., Wei Li   +6 more
doaj  

Embedding the radial basis function neural network based PID controller in a microcontroller for controlling the cart's position in real-time [PDF]

FME Transactions
Proportional integral derivative (PID) is a classic conventional controller and widely utilized in industry. However, its coefficients are normally chosen by using empirical methods.
Nguyen Hoang-Dung, Le Thanh Dai, Tran Tuan Kiet, Huynh The Hien   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Identification of the Interaction Coefficients in an Intraspecific Competition Model with Diffusion Terms

Journal of Mathematics
In this paper, we are interested in identifying the coefficients of the interaction terms in a parabolic system, which describes two subpopulations of the same species competing for the same resources.
Yang Na, Hongyue Wang, Runmei Du, Lina Hao   +3 more
doaj   +1 more source