Results 141 to 150 of about 16,569,160 (252)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Evolution of the Performance of the Malaria Control Program in Burkina Faso: Analysis from 2020 to 2024. [PDF]

J Epidemiol Glob Health
Ouedraogo WD, Kabore A, Kompaore S, Somda S, Sie A, Sawadogo H, Meda ZC, Drabo M, Meda N, Hien H.   +9 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Corrigendum: A Meta-Analysis of the Effect of Bacillus Calmette-Guérin Vaccination Against Bovine Tuberculosis: Is Perfect the Enemy of Good?

Frontiers in Veterinary Science, 2021
Sreenidhi Srinivasan, Sreenidhi Srinivasan, Andrew J. K. Conlan, Laurel A. Easterling, Christian Herrera, Christian Herrera, Premanshu Dandapat, Maroudam Veerasami, Gobena Ameni, Naresh Jindal, Gopal Dhinakar Raj, James Wood, Nick Juleff, Douwe Bakker, Martin Vordermeier, Martin Vordermeier, Vivek Kapur, Vivek Kapur   +17 more
doaj   +1 more source

Analyzing infection prevention and control program in Egyptian university hospitals: strengths and areas for improvement. [PDF]

Antimicrob Resist Infect Control
Ramadan M, Hanafi NF, Aboelenein AM, Abdel-Aziz A, Elsayed AE, Arabi M, Owais HM.   +6 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Calculation of Oregon TB Program indicators

Accompanied by supplement: Calculation of Oregon TB Program indicators.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Evaluation of the National Viral Hepatitis Control Program in Uttarakhand: A mixed-method approach. [PDF]

J Family Med Prim Care
Pandey P, Gupta R, Badola M, Rahul A, Anjali M, Saxena G, Kumar P, Sadasivan A, Bhadoria AS.   +8 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Tuberculosis incidence and mortality trends in mainland China, 2004-2024: control program and elimination progress. [PDF]

Trop Med Health
Mu C, Jia Y, Feng M, Zhao Y, Fan S, Li X.   +5 more
europepmc   +1 more source