Results 91 to 100 of about 7,697,986 (294)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Oñati Socio-Legal Series, 2022 Recent years have witnessed an explosion of interest in predictive policing, with a clear opposition emerging between supporters and critics of its implementation.
Carlo Gatti
doaj
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Revista Simetria do Tribunal de Contas do Município de São Paulo, 2016 O presente estudo apresenta uma reflexão sobre o controle social, tendo como marco histórico a década de 1990, período das primeiras regulamentações da Constituição Federal de 1988. A escolha do tema deriva do fato de que a participação social de forma institucionalizada, objeto de estudos por parte de diversos pesquisadores, desperta interesse não ...
openaire +1 more source
The Performance Implications of Fit Among Environment, Strategy, Structure, Control System and Social Performance [PDF]
, 2013 Purpose – The paper examined concept of corporate performance. The paper seeks to examine the impact of corporate social performance on the relationship among business environment, strategy, organization, and control system and corporate performance.
Fauzi, Hasan
core
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2019 El estudio tuvo como objetivo discutir los conflictos de la internación compulsiva de consumidores de crack. Se realizó una revisión sistemática sobre el tratamiento compulsivo. La búsqueda fue realizada en las bases de datos: Scopus, PubMed, SciELO, Web
Aldo Pacheco Ferreira +5 more
doaj
Two theoretical dimensions of the cyber hate crime [PDF]
, 2017 The impact and relationship between technologies and society establish the development of certain adaptive models, based on coexistence (Human-information-Machine), as well as several behavioral and cognitive changes of the human being, and new models of
Salas, Cesar Rommel
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source