Results 121 to 130 of about 1,948,952 (310)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Promotion of smoking through social media : implications for social marketing
, 2014 Social marketing has been widely used to affect health-related behaviours by either creating positive images of healthy behaviours e.g. ‘eat right’ (Evans, 2008) or by focusing on negative appeals, such as those used in road-safety campaigns (Hastings ...
Soboleva, Alena (R17462) +2 more
core
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Consumer-Centric Protection for Online Social Networks
, 2014 Online Social Networks (OSNs) are a unique construct that is shaped by the advancement and availability of Internet technologies. A large portion of internet users make use of OSN services to share and celebrate their personal lives with friends and ...
Tsz Fung Law +7 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The social control–social capital debate about distance and online teacher education: critical reflections on two courses at the University of Southern Queensland, Australia [PDF]
, 2006 [Abstract]: One among several crucial conceptual lenses that should be deployed in interrogating the effectiveness of an open learning approach to teacher education is the social control–social capital debate.
Danaher, Patrick Alan
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Estudios AtacameñosEste artículo analiza la creación del departamento de Bienestar Social de la Asociación de Productores de Salitre de Chile, en el contexto de la crisis económica de principios de la década de 1920.
Pablo Artaza Barrios
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Rapid literature review of smoking cessation and tobacco control issues across criminal justice system settings [PDF]
, 2010 This review was undertaken to inform the development of the Regional Criminal Justice Coordinator role in the North West Region. It was conducted by the Institute for Social Marketing at the University of Stirling and involved a rapid review of ...
MacDonald, Laura +3 more
core