Results 101 to 110 of about 6,425,712 (293)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modelling alternative management strategies of invasive tree species at the expansion front: Ligustrum lucidum as a case study

Ecological Solutions and Evidence
Managing invasive non‐native species is a global challenge, especially for long‐lived trees like Ligustrum lucidum, known for its detrimental effects on invaded ecosystems.
Lia Montti, Stephen C. F. Palmer, Priscila A. Powell, David F. R. P. Burslem, Justin M. J. Travis, Aurore Ponchon   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Guidance and Control strategies for aerospace vehicles [PDF]

A neighboring optimal guidance scheme was devised for a nonlinear dynamic system with stochastic inputs and perfect measurements as applicable to fuel optimal control of an aeroassisted orbital transfer vehicle.
Charalambous, C. D., Hibey, J. L., Naidu, D. S.   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Africa’s response to COVID-19

BMC Medicine, 2020
Chikwe Ihekweazu, Emmanuel Agogo
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Effects of Aqueous Extracts of Lantana camara L. on Germination of Setaria viridis (L.) P.Beauv. Seeds with Different Degrees of Dormancy

Seeds
Setaria viridis (green foxtail) is an invasive weed species in various agricultural systems, prompting the search for effective compounds to control its germination.
Marcelly Eduarda da Cunha Lázaro-dos-Santos, Nadine Tonelli Cavalari, Everson dos Santos Ribeiro, Henrique Henning Boyd da Cunha, Livia Marques Casanova, Fernanda Reinert, Bianca Ortiz-Silva, Luana Beatriz dos Santos Nascimento   +7 more
doaj   +1 more source

Synthesis of nonlinear control strategies from fuzzy logic control algorithms [PDF]

Fuzzy control has been recognized as an alternative to conventional control techniques in situations where the plant model is not sufficiently well known to warrant the application of conventional control techniques. Precisely what fuzzy control does and
Langari, Reza
core   +1 more source