Results 131 to 140 of about 2,306,933 (257)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Review on lead poisoning in domestic animals: <i>Prevention and control strategies</i>. [PDF]

Vet Anim Sci
Hailu F, Mulugeta Y.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Building-Tailored Hierarchical Electrochromism with Optimized Control Strategies. [PDF]

Adv Sci (Weinh)
Wu S, Sun J, Duan Z, Li X, Xiao J, Sun H, Lin B.   +6 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Fostering Local Ownership of Infection Prevention and Control Strategies: A Multi-country Program. [PDF]

Ann Glob Health
McCann NC, Kaiser JL, Scott NA, Hafner T, Zagorski A, Joshi MP, Alombah F, Morgan AJ, Requejo Domínguez JA, Wirtz VJ.   +9 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Altered weight-bearing compensatory neuromuscular control strategies in early-stage hip-related pain. [PDF]

Front Sports Act Living
Lin Q, Ren M, Jin J, Wang J, Hou J, Sun Q, Huo B, Lin J.   +7 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mechanistic Landscape and Farm to Fork Control Strategies for <i>Streptococcus suis</i>: An Emerging Foodborne Threat. [PDF]

Transbound Emerg Dis
Yao W, Chen M, Ren H, Luo Q, Wang X, Akhtar M, Bhutta ZA, Peng L, Nawaz MY, Hasan MM, Kulyar MF, Fang R.   +11 more
europepmc   +1 more source