Results 111 to 120 of about 6,255,077 (334)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Vibration Control Strategy of Rotor System Using Variable Stiffness Support

Shanghai Jiaotong Daxue xuebao
This paper focuses on vibration control strategies utilizing active variable stiffness support for rotor systems in aero-engine structures, which aims to mitigate the negative impact of multi-order resonance on structural reliability.
JIN Fuyi, ZANG Chaoping, XING Guangpeng, MA Yuxiang, YUAN Shanhu, JIA Zhigang
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Modern Strategies for Controlling Wind Power Plants: Technologies, Challenges and Prospects

Energy Engineering and Control Systems
This paper explores the evolution of wind power plant (WPP) control strategies, from simple approaches aimed at optimizing the operation of individual wind turbines to the development of more complex systems that manage WPPs as single integrated entities.
Nazarii Kurylko, Roman Fedoryshyn
doaj   +1 more source

DEVELOPMENT AND ANALYSIS OF CONTROL STRATEGY FOR BATTERY TO ENHANCE THE LIFE OF THE BATTERY WITH THE APPLICATION OF ULTRA CAPACITOR

, 2021
Kusum Lata, Jai Kumar Maherchandani, Sujit Kumar   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

An Additional Damping Control Strategy for Grid-Forming Energy Storage to Address Low-Frequency Oscillation

Energies
Grid-forming (GFM) energy storage can be utilized as a backup power source for the power grid to ensure the security of the power grid. GFM energy storage can also enhance the strength of the power grid and improve its stability.
Chi Tian, Jianyuan Xu, Xin Lin, Gaole Yu, Weidong Chen   +4 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

MATHEMATICAL MODELLING OF SMOKING BEHAVIOR: TREATMENT AND PREVENTION OPTIMAL CONTROL

Barekeng
Smoking remains a critical global public health challenge, with both traditional tobacco use and the rising prevalence of e-cigarettes contributing to significant morbidity and mortality. This study introduces a novel mathematical model that captures the
Ananda Noersena, Fatmawati Fatmawati, Cicik Alfiniyah, Afeez Abidemi   +3 more
doaj   +1 more source