Results 141 to 150 of about 1,249,978 (297)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 2021 At present, the methods based on using linearized dynamical equations are applied for syn- thesis of an attitude control system of a satellite with nonlinear dynamics.
Moldabekov, Meirbek +3 more
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Fuzzy control and its application to a pH process [PDF]
In the chemical industry, the control of pH is a well-known problem that presents difficulties due to the large variations in its process dynamics and the static nonlinearity between pH and concentration. pH control requires the application of advanced
Huang, Kuo-En
core
Robust Control Synthesis for Gust Load Alleviation from Large Aeroelastic Models with Relaxation of Spatial Discretisation [PDF]
, 2012 04/03/14 meb. Ok to add, authors retain copyright.This paper introduces a methodology for the design of gust load control systems directly from large aeroelastic models with relaxation of spatial discretisation. A convenient state-space representation of
Ng, BF +3 more
core
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Simultaneous Optimisation of Dynamic Power, Area and Delay in Behavioural Synthesis
, 2000 Concern over power dissipation coupled with the continuing rise in system size and complexity means that there is a growing need for high-level design tools capable of automatically optimising systems to take into account power dissipation, in addition ...
Williams, A.C. +2 more
core
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source