Results 131 to 140 of about 28,036,800 (305)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

From System Level Synthesis to Robust Closed-loop Data-Enabled Predictive Control [PDF]

Willems' fundamental lemma and system level synthesis both characterize a linear dynamic system by its input/output sequences. In this work, we show that the extension of the fundamental lemma in uncertain LTI systems is equivalent to the system level ...
Lian, Yingzhao, Jones, Colin N.
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Style and Prosody control for Zero-shot Speech Synthesis

Modern text-to-speech (TTS) systems are often trained on vast datasets encompassing diverse speakers, styles, and conditions, resulting in a wide spectrum of potential outputs.
Kakouros, Sofoklis, Le Maguer, Sébastien, Suni, Antti, Törö, Tuukka, Šimko, Juraj   +4 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Aircraft Pitch Control Via Parametric Identification and PID Optimization

RUDN Journal of Engineering Research
A comprehensive methodology for designing an aircraft pitch angle control system is proposed, combining mathematical modeling, aerodynamic parameter identification, and controller optimization.
Lin Aung San
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A 3D Multi-Plate Environment for Sound Synthesis [PDF]

, 2013
In this paper, a physics-based sound synthesis environment is presented which is composed of several plates, under nonlinear conditions, coupled with the surrounding acoustic field.
Torin, Alberto, Bilbao, Stefan
core  

Amidst centralized and distributed frequency control in power systems

, 2016
We propose a novel frequency control approach in between centralized and distributed architectures, that is a generalized continuous-time feedback control version of the dual decomposition optimization method.
GRAMMATICO, SERGIO, Florian Dorfler, Sergio Grammatico, Dörfler, F., Grammatico, S, Dörfler, Florian, Dörfler, F, Grammatico, S.   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source