Results 161 to 170 of about 1,516,339 (269)

A cell-free system for 1,6-hexanediamine synthesis using bulk chemical caprolactam as the feedstock. [PDF]

Synth Syst Biotechnol
Liu R, Li C, Zhang Y, Li G, Deng Y.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Engineering Chondroitinase-Free Baculovirus-Insect Cell Expression System for Efficient Synthesis of Chondroitin Sulphates. [PDF]

Microb Biotechnol
Li J, Tian Y, She L, Liu Z, Zhou Y, Wang Y, Zhang J, Zhu L, Tan H, Li J.   +9 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Creating molecular complexity in the chemoenzymatic synthesis of chlorothricin analogues using tandem Diels-Alderases.

Org Biomol Chem
Devine AJ, Manzo-Ruiz M, Back CR, Zorn K, Hayes MA, Race PR, Willis CL.   +6 more
europepmc   +1 more source

Nanocarrier-Mediated Delivery Systems of Phytochemicals to Enhance and Accelerate Diabetic Wound Healing Processes. [PDF]

Drug Des Devel Ther
Wahyuningsih ES, Muhaimin M, Chaerunisaa AY, Khairinisa MA.   +3 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Intestinal microbial community assessment in patients with different forms of epilepsy and autoimmune encephalitis: An exploratory study. [PDF]

Gut Microbes Rep
Mejía-Granados DM, Kawasaki de Araújo T, Malan-Müller S, Oliveira Ribeiro de Aguiar Araújo PA, Braz Dos Santos LH, Yasuda CL, Koutsodontis Machado Alvim M, Carvalho BS, Cendes F, Lopes-Cendes I.   +9 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Recent Advances in Microbial Levan Production: Strategies for Yield Enhancement and Sustainability. [PDF]

Int J Food Sci
Nkuruemma EN, Albuquerque PBS, Pinheiro IO.   +2 more
europepmc   +1 more source