Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
On Infinite-horizon System Level Synthesis Problems [PDF]
System level synthesis is a promising approach that formulates structured optimal controller synthesis problems as convex problems. This work solves the distributed linear-quadratic regulator problem under communication constraints directly in infinite ...
Yu, Jing, +2 more
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Uniform switched control strategy of valve-controlled asymmetric hydraulic system
Model set of a valve-controlled asymmetric hydraulic system was built, and uniform switched control (USC) strategy was proposed for multi-model set hydraulic system.
Jun Yang +3 more
doaj +1 more source
An application of jλ transformation and discrete oscillation index Md in dynamic synthesis of control system for undersea robot [PDF]
The paper proposes the conversion from z-domain to discrete frequency jλ domain, the basic concept of discrete oscillation index Md, the dynamic synthesis of second order astatic digital following systems and the application of Md in dynamic ...
Xu FA(徐凤安), Li JP(李俊鹏)
core
Optimisation in behavioural synthesis using hierarchical expansion: module ripping [PDF]
During behavioural synthesis, an abstract functional description of a system is mapped automatically onto a physical structure. In a competitive setting, this mapping will be highly optimised - the dataflow is re-arranged, units and registers are ...
Baidas, Z., Williams, A.C., Brown, A.D.
core +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
PROMIS: a statistical-parametric speech synthesis system with prominence control via a prominence network [PDF]
We implement an architecture with explicit prominence learning via a prominence network in Merlin, a statistical-parametric DNN-based text-to-speech system.
Zofia Malisz +7 more
core +1 more source
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Synthesis for Human-in-the-Loop Control Systems [PDF]
Several control systems in safety-critical applications involve the interaction of an autonomous controller with one or more human operators. Examples include pilots interacting with an autopilot system in an aircraft, and a driver interacting with automated driver-assistance features in an automobile.
Wenchao Li 0001 +3 more
openaire +1 more source

