Results 81 to 90 of about 8,336,078 (339)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diagnosis and Repair for Synthesis from Signal Temporal Logic Specifications

, 2016
We address the problem of diagnosing and repairing specifications for hybrid systems formalized in signal temporal logic (STL). Our focus is on the setting of automatic synthesis of controllers in a model predictive control (MPC) framework.
Donze, Alexandre, Ghosh, Shromona, Nuzzo, Pierluigi, Raman, Vasumathi, Sadigh, Dorsa, Sangiovanni-Vincentelli, Alberto, Sastry, S. Shankar, Seshia, Sanjit A.   +7 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Maximally permissive controlled system synthesis for non-determinism and modal logic

Discrete event dynamic systems, 2016
We propose a new technique for controlled system synthesis on non-deterministic automata for requirements in modal logic. Synthesis, as defined in this paper, restricts a behavioral specification of the uncontrolled system such that it satisfies a given ...
A. V. Hulst, M. Reniers, W. Fokkink
semanticscholar   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Combined motion control of hydraulic boom based on dynamic surface adaptive fuzzy sliding mode

The Journal of Engineering, 2018
The lifting mechanism on the transfer vehicle is a common electromechanical–hydraulic system. In order to overcome the non-linear and interference that exist in the hydraulic boom combined motion process, a dynamic surface adaptive fuzzy sliding mode ...
Rongan Pan, Wenzheng Du, Zhenxin He, Yue Jiang, Jie Wang   +4 more
doaj   +1 more source

Research on compliant configuration of hydraulic manipulator with passive following characteristic

The Journal of Engineering, 2020
To decrease the injury caused by an accidental collision between the hydraulic manipulator and human, a hydraulic rotating angle self-servo compliant robot driver joint is designed. Based on this joint, a variable stiffness passive servo-hydraulic rotary
Lin Jiang, Lisheng Ren, Lisheng Ren, Xiaoyue Pan, Jianyang Zhu, Hui Zhao   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

On-line extreme learning algorithm based identification and non-linear model predictive controller for way-point tracking application of an autonomous underwater vehicle

Cognitive Computation and Systems, 2019
In most of the surveillance applications of autonomous underwater vehicle (AUV), very often it is intended to follow the desired horizontal way-points, where some oceanography data need to be collected.
Biranchi Narayan Rath, Bidyadhar Subudhi
doaj   +1 more source

Substructural controller synthesis [PDF]

A decentralized design procedure which combines substructural synthesis, model reduction, decentralized controller design, subcontroller synthesis, and controller reduction is proposed for the control design of flexible structures.
Craig, Roy R., Jr., Su, Tzu-Jeng
core   +1 more source